PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET.

Authors

Hongmei Dong
Wan Lin
Liang Du
Zhimeng Yao
Feifei Li
Shuanglong Chen
Yiteng Huang
Hongzheng Ren
Yichen Luo
Songwang Cai
Yexi Chen
Hui Tang
Xiaofu Qiu
Yunlong Pan
Xingxu Huang
Dianzheng Zhang, Philadelphia College of Osteopathic MedicineFollow
Shegan Gao
Sai-Ching Jim Yeung
Hao Zhang

Document Type

Article

Publication Date

7-28-2023

Abstract

Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO^low/p-MET^high had significantly poor prognosis, suggesting that PTPRO^low/p-MET^high can serve as an independent prognostic factor for patients with ESCC.

Publication Title

Cancer Letters

Volume

567

PubMed ID

37331584

Comments

This article was published in Cancer Letters, Volume 567.

The published version is available at https://doi.org/10.1016/j.canlet.2023.216283.

Copyright © 2023 Elsevier B.V.

Recommended Citation

Dong, Hongmei; Lin, Wan; Du, Liang; Yao, Zhimeng; Li, Feifei; Chen, Shuanglong; Huang, Yiteng; Ren, Hongzheng; Luo, Yichen; Cai, Songwang; Chen, Yexi; Tang, Hui; Qiu, Xiaofu; Pan, Yunlong; Huang, Xingxu; Zhang, Dianzheng; Gao, Shegan; Yeung, Sai-Ching Jim; and Zhang, Hao, "PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET." (2023). PCOM Scholarly Works. 2209.
https://digitalcommons.pcom.edu/scholarly_papers/2209