Document Type
Article
Publication Date
1-1-2020
Abstract
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic or parasympathetic paraganglia (PGLs). About 40% of PPGLs result from germline mutations and therefore they are highly inheritable. Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis including
Publication Title
Frontiers in Endocrinology
Volume
11
PubMed ID
33329393
Recommended Citation
Peng, Song; Zhang, Jun; Tan, Xintao; Huang, Yiqiang; Xu, Jing; Silk, Natalie; Zhang, Dianzheng; Liu, Qiuli; and Jiang, Jun, "The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma" (2020). PCOM Scholarly Papers. 2098.
https://digitalcommons.pcom.edu/scholarly_papers/2098
Comments
This article was published in Frontiers in Endocrinology, Volume 11.
The published version is available at https://doi.org/10.3389/fendo.2020.586857.
Copyright © 2020 Peng, Zhang, Tan, Huang, Xu, Silk, Zhang, Liu and Jiang. CC BY 4.0.