Trifarotene (Aklief) for the Treatment of Acne
Trifarotene (Aklief) is a topical retinoid labeled for the treatment of facial and truncal acne vulgaris in patients nine years and older.1 Similar to other retinoids, its exact mechanism of action is not known, but it may work by normalizing keratinization and by having anti-inflammatory effects through stimulation of retinoic acid receptors.
American Family Physician
Osayande, Amimi and McGraw, Candis, "Trifarotene (Aklief) for the Treatment of Acne" (2020). PCOM Scholarly Papers. 2092.
This article was published in American Family Physician, Volume 102, Issue 8, pages 499-504.
The published version is available at https://www.aafp.org/afp/2020/1015/p499.html.
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