Document Type
Article
Publication Date
1-1-2020
Abstract
Epithelial-to-mesenchymal transition (EMT) is one of the important underlying molecular mechanisms for most types of cancers including bladder cancer. The precise underlying molecular mechanism in EMT-mediated bladder cancer progression is far from completed. LSD1, a histone lysine-specific demethylase, is known to promote cancer cell proliferation, metastasis, and chemoresistance. We found in this study that LSD1 is highly upregulated in bladder cancer specimens, especially those underwent chemotherapy, and the elevated levels of LSD1 are highly associated with bladder cancer grades, metastasis status, and prognosis. Inhibiting or knockdown LSD1 repressed not only EMT process but also cancer progression. Mechanistically, LSD1 complexes with β-catenin to transcriptionally upregulate LEF1 and subsequently enhances EMT-mediated cancer progression. More importantly, LSD1 specific inhibitor GSK2879552 is capable of repressing tumor progression in patient-derived tumor xenograft. These findings altogether suggest that LSD1 can serve as not only a prognostic biomarker but also a promising therapeutic target in bladder cancer treatment.
Publication Title
Frontiers in Oncology
Volume
10
PubMed ID
32850370
Recommended Citation
Xie, Qiubo; Tang, Tang; Pang, Jian; Xu, Jing; Yang, Xingxia; Wang, Linang; Huang, Yiqiang; Huang, Zhuowei; Liu, Gaolei; Tong, Dali; Zhang, Yao; Wang, Luofu; Zhang, Dianzheng; Lan, Weihua; Liu, Qiuli; and Jiang, Jun, "LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT." (2020). PCOM Scholarly Papers. 2079.
https://digitalcommons.pcom.edu/scholarly_papers/2079
Comments
This article was published in Frontiers in Oncology, Volume 10.
The published version is available at https://doi.org/10.3389/fonc.2020.01234.
Copyright © 2020 Xie, Tang, Pang, Xu, Yang, Wang, Huang, Huang, Liu, Tong, Zhang, Wang, Zhang, Lan, Liu and Jiang. CC-BY 4.0.