Ischemia/reperfusion results in cardiac contractile dysfunction and cell death partly due to increased reactive oxygen species and decreased endothelial-derived nitric oxide bioavailability. NADPH oxidase normally produces reactive oxygen species to facil
Chen, Qian; Parker, Woodworth C.; Devine, Issachar; Ondraskik, Regina; Habtamu, Tsion; Bartol, Kyle; Casey, Brendan; Patel, Harsh; Chau, William; and Kuhn, Tarah, "Apocynin Exerts Dose-Dependent Cardioprotective Effects by Attenuating Reactive Oxygen Species in Ischemia/Reperfusion" (2016). PCOM Scholarly Papers. 1681.