Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization
Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. Â© 2007 Elsevier Ltd. All rights reserved.
Bioorganic and Medicinal Chemistry Letters
Edupuganti, O. P.; Antoci, V. Jr.; King, S. B.; Jose, B.; Adams, Christopher S.; Parvizi, J.; Shapiro, I. M.; Zeiger, A. R.; Hickok, N. J.; and Wickstrom, E., "Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization" (2007). PCOM Scholarly Papers. 1561.