Use of the Anti-Inflammatory Cytokine Interleukin-11 to Reverse HIV-1gp120 Repression of a Natural Killer Cell Line
Enhancing natural killer (NK) cell activation has been associated with protection from human immunodeficiency virus-1 (HIV-1) infections and slowed onset of immunodeficiency. However, soluble HIV-1 envelope protein, gp120, has been shown to impair NK cell cytokine secretion and cell-mediated cytotoxicity. Here we show that gp120 suppressed IFN-γ production and cytotoxic function of a human NK cell line NK-92MI. We furthermore demonstrated that an anti-inflammatory cytokine interleukin-11 can restore effector functions to repressed NK-92MI cells. These studies support the notion that IL-11 administration may reduce HIV-1-mediated immune activation and exhaustion while achieving elimination of virally-infected cells through restored NK cell function.
Favors, Sheena E.; Curd, Lindsay M.; and Gregg, Randal K., "Use of the Anti-Inflammatory Cytokine Interleukin-11 to Reverse HIV-1gp120 Repression of a Natural Killer Cell Line" (2012). PCOM Scholarly Papers. 156.
This article was published in Cellular Immunology, Volume 276, Issue 1-2, March-April 2012, Pages 1-5.
The published version is available at http://dx.doi.org/10.1016/j.cellimm.2012.02.011
Copyright © 2012 Elsevier Inc.