Doxepin and imipramine: Effect on catecholamine inhibition of ganglionic transmission
Doxepin (DOX) and imipramine (IM) administered by close intra-arterial injection (25, 40 and 60 Î¼g/kg) potentiated the inhibitory effect of norepinephrine (NE) on electrically-evoked postganglionic potentials in the superior cervical ganglion of the cat. Dose-response relationships indicated no significant difference between DOX and IM with regard to their effect on NE activity. Potentiation of dopamine (DA)-induced suppression of ganglionic transmission by DOX and IM (25, 40 and 60 Î¼g/kg) was not as pronounced as the potentiation of NE activity by these two antidepressants. Significant potentiation of DA was evident only at the 40 and 60 Î¼g/kg dose levels of DOX and IM. Dose-response relationships indicated that potentiation of DA by DOX was significantly greater than that produced by IM. Â© 1975.
Tehrani, J. B.; Rossi, G. V.; and Goldstein, Frederick J., "Doxepin and imipramine: Effect on catecholamine inhibition of ganglionic transmission" (1975). PCOM Scholarly Papers. 1341.