Potentiation of monoaminergic activity in peripheral ganglia by tricyclic antidepressants
Modification of neuromodulator activity by tricyclic antidepressants was evaluated on the basis of changes in transmission in the cat superior cervical ganglion. Intra-arterial doses of 30 Î¼g of desipramine, 90 Î¼g of protriptyline and 120 Î¼g of nortriptyline were equipotent in facilitating the ganglionic depressive action of epinephrine. At these doses, the ganglionic inhibitory effect of norepinephrine was potentiated to a greater extent by protriptyline than by desipramine and nortriptyline; depression of postganglionic potentials by 5-hydroxytryptamine was augmented by desipramine and protriptyline, whereas dopamine was potentiated only by protriptyline. Propranolol, 200 Î¼g, intra-arterially, enhanced the ganglionic suppressive effect of epinephrine but not norepinephrine. Simultaneous administration of propranolol, 200 Î¼g, and desipramine, 30 Î¼g, potentiated the action of epinephrine to a greater extent than either agent alone. Â© 1972.
European journal of pharmacology
Malseed, R. T.; Rossi, G. V.; and Goldstein, Frederick J., "Potentiation of monoaminergic activity in peripheral ganglia by tricyclic antidepressants" (1972). PCOM Scholarly Papers. 1331.