5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions
The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5-HT3R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N-benzyl group, resulted in the discovery of a partial agonist.
Bioorganic and Medicinal Chemistry Letters
Parihar, Harish S.; Suryanarayanan, Asha; Ma, Chun; Joshi, Prasad; Venkataraman, Padma; Schulte, Marvin K.; and Kirschbaum, Karen S., "5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions" (2001). PCOM Scholarly Papers. 1139.
This article was published in Bioorganic and Medicinal Chemistry Letters, Volume 11, Issue 16, Pages 2133-2136.The published version is available at http://dx.doi.org/10.1016/S0960-894X(01)00417-6.
Copyright © 2001 Elsevier.