Electrostatic potential surfaces of 5-HT3R agonists suggest accessory cation-p site adjacent to agonist binding domain
Electrostatic potential surface mapping of various aromatic ring systems contained in 5-HT3R agonists indicate that some agonists contain an aromatic moiety capable of a favorable cation-p interaction next to the e-face of pyridine (or its bioisostere). A pharmacophore model has been proposed based on superimposition of two distinct 'aryl' interactions.
Bioorganic and Medicinal Chemistry Letters
Parihar, Harish S. and Kirschbaum, Karen S., "Electrostatic potential surfaces of 5-HT3R agonists suggest accessory cation-p site adjacent to agonist binding domain" (2002). PCOM Scholarly Papers. 1138.