Recessive dystrophic epidermolysis bullosa: A review of disease pathogenesis and update on future therapies

Document Type

Article

Publication Date

2015

Abstract

Objective: Review the pathogenesis of recessive dystrophic epidermolysis bullosa and provide an update on research currently underway that is aimed at treating and potentially curing this severe skin disorder. Design: Review article. Setting: Private practice and large teaching hospital. Participants: None. Measurements: N/A. Results: Currently, patients with recessive dystrophic epidermolysis bullosa are managed with only supportive care. However, there are several promising new treatment avenues that may help patients in the future. These include gene therapy, cell therapy, and protein-based therapy. Each approach offers distinct advantages and disadvantages. Conclusions: The advances in understanding the molecular basis for epidermolysis bullosa over the last few decades has led to significant progress in devising new treatment options. Though many of these approaches remain several years away from regular implementation, it is an exciting time for research in the field.

Publication Title

Journal of Clinical and Aesthetic Dermatology

Volume

8

Issue

5

First Page

41

Last Page

46

Comments

This article was published in Journal of Clinical and Aesthetic Dermatology, Volume 8, Issue 5, Pages 41-46.

The published version is available at http://www.jcadonline.com/2015/05 .

Copyright © 2015 JCAD/Matrix Medical Communications.

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