Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism

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Objective: To investigate cardiovascular risk factors in women with polycystic ovary syndrome (PCOS) combined with subclinical hypothyroidism (SCH). Patients: A place-controlled study was performed. Group 1: 29 patients with PCOS and SCH; Group II: 35 patients with PCOS and normal thyroid function; and Group III: 34 healthy women with normal thyroid function. Main measure indexes: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), Carotid Arterial Intima-Media Thickness (CIMT), free triiodothyronine 3 (FT3), free triiodothyronine 4 (FT4), thyroid stimulating hormone (TSH), fasting glucose, 1-hour oral glucose tolerance test (OGTT1), 2-hour oral glucose tolerance test (OGTT2), fasting insulin, insulin after 1 hour oral glucose (INS1), insulin after 2h oral glucose (INS2), HOM-IR=(fasting glucose x fasting insulin)/22.5. Results: TG, TC FIN, INS1, and HOM-IR levels were significantly higher, but the mean HDL level was significantly lower in Group I than in Group II (p0.05). TG, TC, FIN and INS contents 2h meal, HOM-IR levels were significantly higher, and the mean HDL cholesterol level was significantly lower in Group I than in Group III (p0.05). Carotid Arterial Intima-Media Thickness (CIMT) was significantly thicker in Group I than other two groups. Conclusions: The PCOS patients combined with SCH have higher risk of cardiovascular risk factors than in controls or in patients with PCOS.

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Gynecological Endocrinology





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This article was published in Gynecological Endocrinology, Volume 30, Issue 8, Pages 553-556.

The published version is available at http://dx.doi.org/10.3109/09513590.2013.829443.

Copyright © 2014 Informa.

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