Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism

Authors

Y. Pei
A. Wang
Y. Zhao
L. Yan
M. Li
Richard E. White, Philadelphia College of Osteopathic MedicineFollow
G. C. Han

Document Type

Article

Publication Date

2014

Abstract

Objective: To investigate cardiovascular risk factors in women with polycystic ovary syndrome (PCOS) combined with subclinical hypothyroidism (SCH). Patients: A place-controlled study was performed. Group 1: 29 patients with PCOS and SCH; Group II: 35 patients with PCOS and normal thyroid function; and Group III: 34 healthy women with normal thyroid function. Main measure indexes: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), Carotid Arterial Intima-Media Thickness (CIMT), free triiodothyronine 3 (FT3), free triiodothyronine 4 (FT4), thyroid stimulating hormone (TSH), fasting glucose, 1-hour oral glucose tolerance test (OGTT1), 2-hour oral glucose tolerance test (OGTT2), fasting insulin, insulin after 1 hour oral glucose (INS1), insulin after 2h oral glucose (INS2), HOM-IR=(fasting glucose x fasting insulin)/22.5. Results: TG, TC FIN, INS1, and HOM-IR levels were significantly higher, but the mean HDL level was significantly lower in Group I than in Group II (p0.05). TG, TC, FIN and INS contents 2h meal, HOM-IR levels were significantly higher, and the mean HDL cholesterol level was significantly lower in Group I than in Group III (p0.05). Carotid Arterial Intima-Media Thickness (CIMT) was significantly thicker in Group I than other two groups. Conclusions: The PCOS patients combined with SCH have higher risk of cardiovascular risk factors than in controls or in patients with PCOS.

Publication Title

Gynecological Endocrinology

Volume

30

Issue

8

First Page

553

Last Page

556

Comments

This article was published in Gynecological Endocrinology, Volume 30, Issue 8, Pages 553-556.

Copyright © 2014 Informa.

Recommended Citation

Pei, Y.; Wang, A.; Zhao, Y.; Yan, L.; Li, M.; White, Richard E.; and Han, G. C., "Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism" (2014). PCOM Scholarly Works. 1071.
https://digitalcommons.pcom.edu/scholarly_papers/1071