Location
Moultrie, GA
Start Date
7-5-2025 1:00 PM
End Date
7-5-2025 4:00 PM
Description
INTRODUCTION
Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) syndrome is a rare, hereditary autoinflammatory disorder characterized by the presence of all three dermatological conditions. While PASH syndrome has only recently been identified, there is growing evidence linking pyoderma gangrenosum to kidney dysfunction. However, the relationship between kidney impairment and PASH syndrome remains largely unexplored. Understanding the potential impact of PASH syndrome on renal function is critical not only for advancing our knowledge of this rare condition, but also for improving patient management and treatment strategies. This case study aims to investigate the effect of PASH syndrome on kidney function through the examination of an 81-year-old male human cadaver.
METHODS
This is an observational cadaveric case study evaluating the impact of PASH syndrome on renal function. The study involved the dissection and anatomical analysis of an 81-year-old human cadaver with documented history of chronic PASH syndrome, exhibiting all three dermatological conditions. Each of the human cadavers’ kidneys were dissected to assess structural abnormalities and signs of pathology. Tissue samples from both kidneys were collected and preserved for histological analysis conducted at Colquitt Regional Medical Center. Renal morphology and presence of interstitial fibrosis, glomerulosclerosis, inflammation, or other pathological findings were considered as indicators of kidney dysfunction. Kidney morphology was compared to anatomical norms and previous research evaluating kidney changes associated with autoinflammatory disorders.
RESULTS
The examination of the 81-year-old human cadaver with confirmed PASH syndrome revealed several notable findings relating to kidney structure and signs of pathology within each kidney. Upon dissection, each kidney was of normal size compared to anatomical norms. A large renal cyst was identified on the renal capsule of the left kidney. The cyst was unilocular with a smooth surface. No immediate signs of rupture or infection were present. The right kidney did not show any significant macroscopic abnormalities. The histological examination of kidney tissues demonstrated the presence of interstitial fibrosis, sclerosis of the glomeruli, and increased inflammatory cells, which are all indicative of kidney dysfunction.
DISCUSSION
This cadaveric study provides evidence that PASH syndrome impacts kidney function, as demonstrated by the histological changes observed in the kidneys of the 81-year-old human cadaver. The presence of significant interstitial fibrosis, glomerular sclerosis, and increased inflammatory cells suggests that PASH syndrome may lead to kidney dysfunction. The findings demonstrate the potential for progressive renal dysfunction in individuals with this rare autoinflammatory disorder. Future studies involving a larger sample size and clinical evaluations are essential to confirm these findings and explore potential treatment methods aimed at preserving kidney function in individuals with PASH syndrome.
Embargo Period
6-3-2025
Included in
Evaluation of chronic pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) syndrome and its effect on kidney function: A cadaveric study.
Moultrie, GA
INTRODUCTION
Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) syndrome is a rare, hereditary autoinflammatory disorder characterized by the presence of all three dermatological conditions. While PASH syndrome has only recently been identified, there is growing evidence linking pyoderma gangrenosum to kidney dysfunction. However, the relationship between kidney impairment and PASH syndrome remains largely unexplored. Understanding the potential impact of PASH syndrome on renal function is critical not only for advancing our knowledge of this rare condition, but also for improving patient management and treatment strategies. This case study aims to investigate the effect of PASH syndrome on kidney function through the examination of an 81-year-old male human cadaver.
METHODS
This is an observational cadaveric case study evaluating the impact of PASH syndrome on renal function. The study involved the dissection and anatomical analysis of an 81-year-old human cadaver with documented history of chronic PASH syndrome, exhibiting all three dermatological conditions. Each of the human cadavers’ kidneys were dissected to assess structural abnormalities and signs of pathology. Tissue samples from both kidneys were collected and preserved for histological analysis conducted at Colquitt Regional Medical Center. Renal morphology and presence of interstitial fibrosis, glomerulosclerosis, inflammation, or other pathological findings were considered as indicators of kidney dysfunction. Kidney morphology was compared to anatomical norms and previous research evaluating kidney changes associated with autoinflammatory disorders.
RESULTS
The examination of the 81-year-old human cadaver with confirmed PASH syndrome revealed several notable findings relating to kidney structure and signs of pathology within each kidney. Upon dissection, each kidney was of normal size compared to anatomical norms. A large renal cyst was identified on the renal capsule of the left kidney. The cyst was unilocular with a smooth surface. No immediate signs of rupture or infection were present. The right kidney did not show any significant macroscopic abnormalities. The histological examination of kidney tissues demonstrated the presence of interstitial fibrosis, sclerosis of the glomeruli, and increased inflammatory cells, which are all indicative of kidney dysfunction.
DISCUSSION
This cadaveric study provides evidence that PASH syndrome impacts kidney function, as demonstrated by the histological changes observed in the kidneys of the 81-year-old human cadaver. The presence of significant interstitial fibrosis, glomerular sclerosis, and increased inflammatory cells suggests that PASH syndrome may lead to kidney dysfunction. The findings demonstrate the potential for progressive renal dysfunction in individuals with this rare autoinflammatory disorder. Future studies involving a larger sample size and clinical evaluations are essential to confirm these findings and explore potential treatment methods aimed at preserving kidney function in individuals with PASH syndrome.
Comments
Awarded "Best Cadaver/ Biomed Project" at PCOM South Georgia Research Day 2025.