Location
Suwanee, GA
Start Date
6-5-2025 1:00 PM
End Date
6-5-2025 4:00 PM
Description
Introduction:
This case study examines the anatomical and clinical features of a 76-year-old cadaver with Androgen Insensitivity Syndrome (AIS), an X-linked recessive disorder causing androgen resistance, resulting in the feminization of 46, XY individuals. Our case study highlights AIS classification, clinical manifestations, and management strategies, including the risks of testicular cancer, gonadectomy, hormone replacement therapy, and psychological considerations, emphasizing a multidisciplinary approach for optimal patient care.
Methods:
Gross anatomical dissection was conducted to assess the external and internal structures, with high-resolution images captured and enhanced for clarity. Precise measurements were taken and compared to typical female anatomy in order to ascertain the anatomical variations found in AIS.
Results:
The donor, identified as female on the death certificate, exhibited predominantly female external characteristics, including a clitoris, labia, and a blind-ending vaginal pouch; however, internal structures revealed male reproductive anatomy, including a prostate, seminal vesicles, and undescended gonads.
Discussion/Conclusions:
The anatomical results align with a diagnosis of complete androgen insensitivity syndrome (CAIS), where external feminization occurs despite the presence of male internal reproductive structures. This case underscores the complexities of CAIS, emphasizing the need for a multidisciplinary approach to patient management. Key considerations include the risks associated with gonadectomy, hormone therapy, cancer screening, and psychosocial support. By highlighting anatomical variations and clinical challenges, this study contributes to the broader understanding of intersex conditions and informs best practices for medical care.
Embargo Period
5-28-2025
Included in
Complete Androgen Insensitivity Syndrome in a 76 year-old Cadaver
Suwanee, GA
Introduction:
This case study examines the anatomical and clinical features of a 76-year-old cadaver with Androgen Insensitivity Syndrome (AIS), an X-linked recessive disorder causing androgen resistance, resulting in the feminization of 46, XY individuals. Our case study highlights AIS classification, clinical manifestations, and management strategies, including the risks of testicular cancer, gonadectomy, hormone replacement therapy, and psychological considerations, emphasizing a multidisciplinary approach for optimal patient care.
Methods:
Gross anatomical dissection was conducted to assess the external and internal structures, with high-resolution images captured and enhanced for clarity. Precise measurements were taken and compared to typical female anatomy in order to ascertain the anatomical variations found in AIS.
Results:
The donor, identified as female on the death certificate, exhibited predominantly female external characteristics, including a clitoris, labia, and a blind-ending vaginal pouch; however, internal structures revealed male reproductive anatomy, including a prostate, seminal vesicles, and undescended gonads.
Discussion/Conclusions:
The anatomical results align with a diagnosis of complete androgen insensitivity syndrome (CAIS), where external feminization occurs despite the presence of male internal reproductive structures. This case underscores the complexities of CAIS, emphasizing the need for a multidisciplinary approach to patient management. Key considerations include the risks associated with gonadectomy, hormone therapy, cancer screening, and psychosocial support. By highlighting anatomical variations and clinical challenges, this study contributes to the broader understanding of intersex conditions and informs best practices for medical care.
Comments
Awarded "Best Cadaver/Biomed Project: Runner Up" at PCOM Georgia Research Day 2025