Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies


OBJECTIVE: The objective of this selective EBM review is to determine whether or not fecal microbiota transplantation improves symptoms in adults with Irritable Bowel Syndrome.

STUDY DESIGN: A systematic review of two randomized controlled trials and one case series published in English and after 2009.

DATA SOURCES: All three studies were collected from peer-reviewed journals. Databases searched included Cochrane Collaboration and PubMed.

OUTCOMES MEASURED: Outcomes measured included Bristol Stool Form Scale and IBS Severity Scoring System (IBS-SSS).

RESULTS: Halkjær et al. revealed that the placebo FMT had a significant effect (p=0.008) at reducing IBS symptom severity in comparison to the FMT three months after transplantation. Johnsen et al. found that, at three months post-FMT, the treatment group showed a statistically significant effect (p=0.049) at reducing symptom severity. Mizuno et al. showed that six out of the 10 patients achieved a clinical improvement in stool form four weeks following FMT.

CONCLUSIONS: Out of the three articles reviewed, two found that FMT treatment group improved symptoms and one found that the control group given the placebo had a greater effect in improving symptoms.