Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

Laura Levy, DHSc, PA-C


Objective: The objective of this selective EBM review is to determine whether or not Sinupret (BNO 1016- herbal combination) is an effective treatment for the symptoms of acute and chronic rhinosinusitis compared to non-treatment in male and female adults ages 18-75? Study Design: This is a systematic review of three randomized controlled trials (RCTs) regarding Sinupret treatment for sinonasal symptoms. All RCTs were published in the English language in peer-reviewed journals in 2011, 2015, and 2017. Data Sources: Three randomized controlled trials were found using PubMED and CINAHL databases. Outcomes Measured: Symptom relief of acute and chronic rhinosinusitis was measured via major symptom score (MSS) of rhinorrhea, post-nasal drip, congestion, headache, and facial pressure by participants (measured by mean change from baseline). Assessment of responders vs. non-responders to treatment as designated by “cured/improved” vs. “unchanged/deteriorated.” Improvement of olfactory function per phenylethanol odor testing as well as odor discrimination and identification testing. Results: Jund et al.3 showed a greater decrease in acute viral sinusitis symptoms (MSS decrease) with Sinupret treatment than with placebo-treated group (p<0.0001) as well as a NNT of 10. Palm et al.6 showed similar reduction in MSS in the use of Sinupret for chronic sinusitis (p<0.0015). Reden et al. 7 showed improvement in olfactory function in sinusitis patients withdrawing from prednisolone with the use of Sinupret, but failed to show statistical significance (p=0.67). Conclusions: Two of the three studies reviewed studies revealed that Sinupret, herbal combination, can be used as an effective treatment in adults 18-75 years old for decreasing the symptoms of acute viral and chronic sinusitis at a faster rate than no treatment at all. Multiple studies suggested expanding the study population beyond German participants.