Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


Objective: The objective of this selective EBM review is to determine whether or not “Does Lactobacillus reuteri DSM 17938 reduce daily crying times in infants with colic?”

Study Design: Review of all English language primary studies published in 2010, 2013, 2015.

Data Sources: Three randomized, double blind, placebo controlled clinical trials found using PubMed.

Outcomes Measured: Daily average crying times were measured by parents who documented these in a journal.

Results: In all three randomized control studies by Chaeu et al. (2015), Savino et al, (2010), and Szajewska et al. (2013), they found that infants with colic given Lactobacillus reuteri DSM 17938 had reduced daily crying times as documented by the parents compared to the infants with colic given a placebo that looked and tasted the same.

Conclusion: All three randomized control trials included in this review indicate that Lactobacillus reuteri DSM 17938 reduces the daily crying times in infants with colic.

Included in

Pediatrics Commons