Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


OBJECTIVE The objective of this selective EBM review is to determine whether the Chinese herbal supplement, Ningdong granule, is a safe and effective alternative to haloperidol for the treatment of tic symptoms in pediatric patients with Tourette Syndrome.

STUDY DESIGN Systematic review of three randomized controlled trials published in 2009, 2010, and 2012.

DATA SOURCES Three randomized controlled trials were obtained using PubMed.

OUTCOMES MEASURED Efficacy of Ningdong granule (NDG) as compared to control groups based on decrease in tic severity and frequency as reported by Yale Global Tic Severity Scale as well as safety, as evidenced by prevalence of adverse drug reactions (ADRs) as compared to control groups.

RESULTS Li et al. (2009), Wang et al. (2012), and Zhao et al. (2010) all demonstrated improvement in a majority of the subjects’ tic symptoms while decreasing ADR’s from treatment with Ningdong granule compared to haloperidol.

CONCLUSION Evidence to support the efficacy of Ningdong granule to safely treat tic symptoms in pediatric Tourette Syndrome patients is strong now, due to a relevant subject population, and consistent standard of measurement. The data strongly supports the efficacy of Ningdong granule as an alternative method of treating tic symptoms in pediatric patients suffering from Tourette Syndrome.