Date of Award
Selective Evidence-Based Medicine Review
Master of Science in Health Sciences - Physician Assistant
Physician Assistant Studies
John Cavenagh, MBA, PhD, PA-C
Objective: The objective of this selective EBM review is to determine whether or not “Submental deoxycholic acid injections reduce submental fat in adult patients enough to create a significant increase in patient satisfaction”
Study Design: Review of 3 double blind, randomized control trials that were selected based on their relevance to the clinical question.
Data Sources: All three peer-reviewed articles were found using PubMed and Cochrane Database. The keywords “ATX-101”, “submental fat”, and “deoxycholic acid” were used.
Outcomes Measured: Satisfaction with appearance in association with face and chin evaluated by a patient reported subject self-rating scale (PR-SSRS), a numeric scale with values from 0-6.
Results: All three trials recorded significant improvement in subject satisfaction compared to placebo with a p-value
Conclusion: Deoxycholic acid injections to the submental region resulted in a consistent improvement in patients’ satisfaction with the appearance of their submental region. The NNT values are low proving these injections to be effective in improving satisfaction.
Curry, Alec W., "Do Submental Deoxycholic Acid Injections Reduce Submental Fat in Adult Patients Enough to Create a Significant Increase in Patient Satisfaction?" (2017). PCOM Physician Assistant Studies Student Scholarship. 403.