Alec W. Curry

Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


Objective: The objective of this selective EBM review is to determine whether or not “Submental deoxycholic acid injections reduce submental fat in adult patients enough to create a significant increase in patient satisfaction”

Study Design: Review of 3 double blind, randomized control trials that were selected based on their relevance to the clinical question.

Data Sources: All three peer-reviewed articles were found using PubMed and Cochrane Database. The keywords “ATX-101”, “submental fat”, and “deoxycholic acid” were used.

Outcomes Measured: Satisfaction with appearance in association with face and chin evaluated by a patient reported subject self-rating scale (PR-SSRS), a numeric scale with values from 0-6.

Results: All three trials recorded significant improvement in subject satisfaction compared to placebo with a p-value

Conclusion: Deoxycholic acid injections to the submental region resulted in a consistent improvement in patients’ satisfaction with the appearance of their submental region. The NNT values are low proving these injections to be effective in improving satisfaction.

Included in

Dermatology Commons