Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


OBJECTIVE: The objective of this selective EBM review is to determine whether or not 100mg Flibanserin is effective in increasing the number of sexually satisfying events in women with HSDD.

STUDY DESIGN: Review of three, placebo-controlled trials in which women > 18 years old with HSDD were treated with either 100mg Flibanserin or a Placebo once daily qhs for 24 weeks

DATA SOURCES: Three randomized, placebo-controlled trials found via PubMed searches and published in English peer-reviewed journals between 2011-2014

OUTCOMES MEASURED: Outcomes measured were the number of SSE over 4 weeks and analyzed with Wilcoxon’s rank-sum test.

RESULTS: In DeRogatis et al, 100mg Flibanserin led to increases in the mean (standard error) SSE 1.6 (0.23) vs 0.80 (0.20) and was proven to be statistically significant (p

CONCLUSIONS: Based on this review, 100mg Flibanserin taken once daily qhs is effective and well tolerated in treating those with HSDD in both pre- and postmenopausal women. The mean number of SSE was statistically significant vs. placebo in all three studies.