Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


Objective: The objective of this evidence based medicine review is to determine whether or not Juvederm Ultra Plus is effective in treating nasolabial fold wrinkles over a one year period.

Study Design: Three blinded, randomized controlled trials were reviewed and selected based on their relevance to the clinical question and their inclusion of patient oriented outcomes (POEMS).

Data Sources: Each study was obtained by searching Cochrane, PubMed databases, and product package insert.

Outcome Measured: The outcomes measured were improvement in NLF wrinkle on a five point Wrinkle Assessment Scale compared to baseline.

Results: The studies by Lupo et al, Goodman et al, and Allergan found a statistically significant reduction in nasolabial fold wrinkles compared to baseline over a one year period after injection with Juvederm Ultra Plus.

Conclusions: The results showed Juvederm Ultra Plus is an effective treatment for nasolabial folds over a one year period, as evidenced by at least a one point reduction in severity of nasolabial fold wrinkles as well as low numbers needed to treat (NNT) for all three studies.