Title

MyoD-Positive Epiblast Cells Regulate Skeletal Muscle Differentiation in the Embryo

Document Type

Article

Publication Date

10-23-2006

Abstract

MyoD mRNA is expressed in a subpopulation of cells within the embryonic epiblast. Most of these cells are incorporated into somites and synthesize Noggin. Ablation of MyoD-positive cells in the epiblast subsequently results in the herniation of organs through the ventral body wall, a decrease in the expression of Noggin, MyoD, Myf5, and myosin in the somites and limbs, and an increase in Pax-3-positive myogenic precursors. The addition of Noggin lateral to the somites compensates for the loss of MyoD-positive epiblast cells. Skeletal muscle stem cells that arise in the epiblast are utilized in the somites to promote muscle differentiation by serving as a source of Noggin.

Publication Title

The Journal of Cell Biology

Volume

175

Issue

2

First Page

283

Last Page

292

PubMed ID

17060497

Comments

This article was published in Journal of Cell Biology, Volume 175, Issue 2, October 23, 2006, Pages 283-292.

The published version is available at http://dx.doi.org/10.1083/jcb.200605037

Copyright © 2006 The Rockefeller University Press

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