Nuclear Notch1 signaling and the regulation of dendritic development

Document Type

Article

Publication Date

2000

Abstract

To understand the function of Notch in the mammalian brain, we examined Notch1 signaling and its cellular consequences in developing cortical neurons. We found that the cytoplasmic domain of endogenous Notch1 translocated to the nucleus during neuronal differentiation. Notch1 cytoplasmic-domain constructs transfected into cortical neurons were present in multiple phosphorylated forms, localized to the nucleus and could induce CBF1-mediated transactivation. Molecular perturbation experiments suggested that Notch1 signaling in cortical neurons promoted dendritic branching and inhibited dendritic growth. These observations show that Notch1 signaling to the nucleus exerts an important regulatory influence on the specification of dendritic morphology in neurons.

Publication Title

Nature neuroscience

Volume

3

Issue

1

First Page

30

Last Page

40

Comments

This article was published in Nature neuroscience, Volume 3, Issue 1, Pages 30-40.

The published version is available at http://dx.doi.org/10.1038/71104.

Copyright © 2000 Nature Publishing Group.

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