Title

Myo/Nog cells in normal, wounded and tumor-bearing skin

Document Type

Article

Publication Date

2012

Abstract

Murine and human skin were examined for the presence of Myo/Nog cells that were originally discovered in the chick embryo by their expression of MyoD mRNA, noggin and the G8 antigen. Myo/Nog cells are the primary source of noggin in telogen hair follicles. They are scarce within the interfollicular dermis and absent in the epidermis. Within 24 h following epidermal abrasion, Myo/Nog cells increase in number in the follicles and appear in the wound. Myo/Nog cells are also recruited to the stroma of tumors formed from v-Ras-transformed keratinocytes (Ker/Ras). Human squamous cell carcinomas and malignant melanomas contain significantly more Myo/Nog cells than basal cell carcinomas. Myo/Nog cells are distinct from macrophages, granulocytes and cells expressing alpha smooth muscle actin in the tumor stroma. Myo/Nog cells may be modulators of skin homoeostasis and wound healing, and potential diagnostic and therapeutic targets in skin cancer.

Publication Title

Experimental dermatology

Volume

21

Issue

6

First Page

466

Last Page

468

Comments

This article was published in Experimental dermatology, Volume 21, Issue 6, Pages 466-468.

The published version is available at http://dx.doi.org/10.1111/j.1600-0625.2012.01503.

Copyright © 2012 Wiley.

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