Frank Stinchfield award: Titanium surface with biologic activity against infection
Document Type
Article
Publication Date
2004
Abstract
Despite immense improvements, periprosthetic infection continues to compromise the result of otherwise successful joint arthroplasty. There are various limitations in the treatment of periprosthetic infection, the most important of which is the inability to deliver antibiotics to the local tissue without the need for intravenous administration. We have developed a novel route to covalently tether vancomycin to a metal (titanium) surface, which showed effective bactericidal activity because of a vancomycin coupling. The chemistry of tethering does not affect the biological activity of the biofactors that are attached to the metal surface. This technology holds great promise for the manufacturing of "smart" implants that can be self protective against periprosthetic infection, or can be used for the treatment of periprosthetic infections when they occur.
Publication Title
Clinical orthopaedics and related research
Issue
429
First Page
33
Last Page
38
Recommended Citation
Parvizi, J.; Wickstrom, E.; Zeiger, A. R.; Adams, Christopher S.; Shapiro, I. M.; Purtill, J. J.; Sharkey, P. F.; Hozack, W. J.; Rothman, R. H.; and Hickok, N. J., "Frank Stinchfield award: Titanium surface with biologic activity against infection" (2004). PCOM Scholarly Works. 1579.
https://digitalcommons.pcom.edu/scholarly_papers/1579
Comments
This article was published in Clinical orthopaedics and related research, Issue 429, Pages 33-38.
The published version is available at http://dx.doi.org/10.1097/01.blo.0000150116.65231.45.Copyright © 2004.