Elevation in analgetic effect and plasma levels of morphine by desipramine in rats

Document Type

Article

Publication Date

1982

Abstract

Pretreatment of rats with desipramine (30 mg/kg, s.c.) enhanced both peak intensity and duration of morphine sulfate (5 mg/kg s.c.) analgesia as determined by measurement of tail flick latency. Morphine concentrations in plasma were also significantly elevated after desipramine. Increased narcotic analgetic responses following desipramine pretreatment appear related to higher circulating levels of unmetabolized morphine. © 1982.

Publication Title

Pain

Volume

14

Issue

3

First Page

279

Last Page

282

Comments

This article was published in Pain, Volume 14, Issue 3, Pages 279-282.

The published version is available at http://dx.doi.org/10.1016/0304-3959(82)90134-8.

Copyright © 1982.

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