5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions

Authors

Harish S. Parihar, Philadelphia College of Osteopathic MedicineFollow
Asha Suryanarayanan
Chun Ma
Prasad Joshi
Padma Venkataraman
Marvin K. Schulte
Karen S. Kirschbaum

Document Type

Article

Publication Date

2001

Abstract

The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5-HT3R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N-benzyl group, resulted in the discovery of a partial agonist.

Publication Title

Bioorganic and Medicinal Chemistry Letters

Volume

11

Issue

16

First Page

2133

Last Page

2136

Comments

This article was published in Bioorganic and Medicinal Chemistry Letters, Volume 11, Issue 16, Pages 2133-2136.

Copyright © 2001 Elsevier.

Recommended Citation

Parihar, Harish S.; Suryanarayanan, Asha; Ma, Chun; Joshi, Prasad; Venkataraman, Padma; Schulte, Marvin K.; and Kirschbaum, Karen S., "5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions" (2001). PCOM Scholarly Papers. 1139.
https://digitalcommons.pcom.edu/scholarly_papers/1139