Title

Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice

Document Type

Article

Publication Date

2004

Abstract

Amyloid deposits resembling plaques found in Alzheimer's disease (AD) brains were formed in the brains of non-transgenic BALB/c mice following intranasal infection with Chlamydia pneumoniae. The mice were infected at 3 months of age with C. pneumoniae isolated from an AD brain. Infection was confirmed by light and electron microscopy in olfactory tissues of the mice. C. pneumoniae was still evident in these tissues 3 months after the initial infection indicating that a persistent infection had been established. Amyloid beta (Aß) 1-42 immunoreactive deposits were identified in the brains of infected BALB/c mice up to 3 months post-infection with the density, size, and number of deposits increasing as the infection progressed. A subset of deposits exhibited thioflavin-s labeling. Intracellular Aß1-42 labeling was observed in neuronal cells. Experimental induction of amyloid deposition in brains of non-transgenic BALB/c mice following infection with C. pneumoniae may be a useful model for furthering our understanding of mechanisms, linked to infection, involved in the initiation of the pathogenesis of sporadic AD.

Publication Title

Neurobiology of aging

Volume

25

Issue

4

First Page

419

Last Page

429

Comments

This article was published in Neurobiology of aging, Volume 25, Issue 4, Pages 419-429.

The published version is available at http://dx.doi.org/10.1016/S0197-4580(03)00127-1.

Copyright © 2004 Elsevier.

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