Location
Philadelphia, PA
Start Date
1-5-2024 1:00 PM
End Date
1-5-2024 4:00 PM
Description
Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease commonly seen in premature infants, characterized by impaired lung development and respiratory complications. Its prevalence has been steadily increasing due to advancements in neonatal care, resulting in improved survival rates of extremely premature infants. This study aims to explore the demographic relationship between gestational age and BPD outcomes, shedding light on the impact of prematurity on disease severity and long-term pulmonary health.
Methods: Data was collected from 1351 patients, with 894 patients from Johns Hopkins and 457 from Children's Hospital of Philadelphia (CHOP) from 2008 to 2023. Three hundred forty-three patients were diagnosed with BPD at a gestational age less than or equal to 24 weeks, 620 patients between the gestational age of 25 to 27 weeks, and 388 patients at a gestational age greater than or equal to 28 weeks. Variables examined include BPD severity, birth weight percentile, sex, race, length of NICU stay, supplemental oxygen usage, and development of pulmonary hypertension.
Results: The study found that among the 1351 patients diagnosed with BPD, the mean gestational age was 26.36 weeks, with a standard deviation of 2.43 weeks. Additionally, 49% of patients were black and 36% were white. Among all the patients, 44% identified that they did not have public insurance. 56% of patients were classified as being diagnosed with severe BPD. The mean birth weight was 897 grams, with the mean birth weight percentile being 41%. The average age at discharge was 91 months, and 39% of patients were on oxygen at the NICU discharge. Furthermore, 22% of patients developed pulmonary hypertension.
Future Studies: Future explorations are focused on assessing long-term outcomes such as the development of asthma, frequency of emergency department visits, and the usage of steroids for respiratory illnesses through questionnaires completed by patients. It is hypothesized that children diagnosed with BPD at younger gestational ages will experience worsened long-term outcomes, which will be explored through the outcome questionnaires. Moreover, there is an expectation of a racial disparity in outcomes, with black children potentially experiencing worsened outcomes compared to other racial groups. Understanding the demographic factors influencing BPD outcomes is crucial for developing targeted interventions and improving the overall care and prognosis of affected infants. By elucidating the relationship between gestational age, race, and long-term pulmonary health outcomes, this study contributes to the broader understanding of BPD and informs clinical practice to better support the needs of at-risk infants.
Embargo Period
7-1-2024
Included in
Exploring the demographic dynamics of bronchopulmonary dysplasia: Insights from a multicenter study
Philadelphia, PA
Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease commonly seen in premature infants, characterized by impaired lung development and respiratory complications. Its prevalence has been steadily increasing due to advancements in neonatal care, resulting in improved survival rates of extremely premature infants. This study aims to explore the demographic relationship between gestational age and BPD outcomes, shedding light on the impact of prematurity on disease severity and long-term pulmonary health.
Methods: Data was collected from 1351 patients, with 894 patients from Johns Hopkins and 457 from Children's Hospital of Philadelphia (CHOP) from 2008 to 2023. Three hundred forty-three patients were diagnosed with BPD at a gestational age less than or equal to 24 weeks, 620 patients between the gestational age of 25 to 27 weeks, and 388 patients at a gestational age greater than or equal to 28 weeks. Variables examined include BPD severity, birth weight percentile, sex, race, length of NICU stay, supplemental oxygen usage, and development of pulmonary hypertension.
Results: The study found that among the 1351 patients diagnosed with BPD, the mean gestational age was 26.36 weeks, with a standard deviation of 2.43 weeks. Additionally, 49% of patients were black and 36% were white. Among all the patients, 44% identified that they did not have public insurance. 56% of patients were classified as being diagnosed with severe BPD. The mean birth weight was 897 grams, with the mean birth weight percentile being 41%. The average age at discharge was 91 months, and 39% of patients were on oxygen at the NICU discharge. Furthermore, 22% of patients developed pulmonary hypertension.
Future Studies: Future explorations are focused on assessing long-term outcomes such as the development of asthma, frequency of emergency department visits, and the usage of steroids for respiratory illnesses through questionnaires completed by patients. It is hypothesized that children diagnosed with BPD at younger gestational ages will experience worsened long-term outcomes, which will be explored through the outcome questionnaires. Moreover, there is an expectation of a racial disparity in outcomes, with black children potentially experiencing worsened outcomes compared to other racial groups. Understanding the demographic factors influencing BPD outcomes is crucial for developing targeted interventions and improving the overall care and prognosis of affected infants. By elucidating the relationship between gestational age, race, and long-term pulmonary health outcomes, this study contributes to the broader understanding of BPD and informs clinical practice to better support the needs of at-risk infants.