Location
Philadelphia, PA
Start Date
1-5-2024 1:00 PM
End Date
1-5-2024 4:00 PM
Description
INTRODUCTION:
Clinical guidelines are utilized in the effort to practice evidence-based medicine. Despite caffeine citrate’s common use in the treatment of apnea of prematurity (AOP) in neonates, there is not a commonly adopted clinical guideline for caffeine therapy. We aim to explore how variation in cited sources influences variation in published recommendations for caffeine therapy in the treatment of apnea of prematurity.
METHODS:
We utilized comparative analysis to identify qualitative variances in clinical guidelines for caffeine therapy to treat apnea of prematurity (AOP) in neonates and bibliometric analysis to identify to what degree citations vary or overlap between clinical guidelines. We analyzed 13 clinical guidelines on caffeine therapy in neonates for treatment of apnea of prematurity (AOP) from 8 different countries or regional bodies, with 165 citations of 108 unique references, to compare clinical recommendations and to measure the qualities and extent of overlap in citations used by different guidelines.
RESULTS:
The recommendations from the selected clinical guidelines had minimal variation in indication and some variation in when to initiate and discontinue caffeine therapy; however, there were key differences in treatment details regarding dosing. Guidelines with shorter differences between their year of publication and their citations’ average year of publication suggested the highest loading and maintenance doses. Guidelines with a higher number of references shared with at least one other guideline overall had the most consistent recommendations. After an additional round of edits with valuable feedback from Dr. Poterjoy, the report from this research will be prepared to submit to various journals and formatted into a poster presentation for Research Day at PCOM on May 1st, 2024.
CONCLUSION:
Identifying variations in clinical guidelines and their sources presents an opportunity for improving care, reducing healthcare spending, and further investigating caffeine therapy treatment in both the inpatient and outpatient settings.
Embargo Period
6-17-2024
Included in
Comparative analysis of caffeine therapy guidelines in neonates
Philadelphia, PA
INTRODUCTION:
Clinical guidelines are utilized in the effort to practice evidence-based medicine. Despite caffeine citrate’s common use in the treatment of apnea of prematurity (AOP) in neonates, there is not a commonly adopted clinical guideline for caffeine therapy. We aim to explore how variation in cited sources influences variation in published recommendations for caffeine therapy in the treatment of apnea of prematurity.
METHODS:
We utilized comparative analysis to identify qualitative variances in clinical guidelines for caffeine therapy to treat apnea of prematurity (AOP) in neonates and bibliometric analysis to identify to what degree citations vary or overlap between clinical guidelines. We analyzed 13 clinical guidelines on caffeine therapy in neonates for treatment of apnea of prematurity (AOP) from 8 different countries or regional bodies, with 165 citations of 108 unique references, to compare clinical recommendations and to measure the qualities and extent of overlap in citations used by different guidelines.
RESULTS:
The recommendations from the selected clinical guidelines had minimal variation in indication and some variation in when to initiate and discontinue caffeine therapy; however, there were key differences in treatment details regarding dosing. Guidelines with shorter differences between their year of publication and their citations’ average year of publication suggested the highest loading and maintenance doses. Guidelines with a higher number of references shared with at least one other guideline overall had the most consistent recommendations. After an additional round of edits with valuable feedback from Dr. Poterjoy, the report from this research will be prepared to submit to various journals and formatted into a poster presentation for Research Day at PCOM on May 1st, 2024.
CONCLUSION:
Identifying variations in clinical guidelines and their sources presents an opportunity for improving care, reducing healthcare spending, and further investigating caffeine therapy treatment in both the inpatient and outpatient settings.