Location

Philadelphia

Start Date

3-5-2017 1:00 PM

Description

Myo/Nog cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (mAb). They are essential for eye development in the chick embryo and respond to injury in adult tissues. G8-positive Myo/Nog cells were present in the postnatal murine retina and they were a distinguished population from neuronal, Muller and microglial cells. In the neonatal retina, we observed the number of Myo/Nog cells increase, in numbers and location, parallel with cell death induced by oxygen-induced stress. Depletion of Myo/Nog cells lead to a substantial increase in cell death in the oxygen-induced retinopathy model. In a light damage model of retinopathy, external addition of purified Myo/Nog cell into the vitreous improved photoreceptor and inner retina neuronal function as measured by full field, flash electroretinogram (ERG). These results suggest that Myo/Nog cells preserve neuronal function from pathologically induced cell stress.

COinS
 
May 3rd, 1:00 PM

Neuroprotection of Myo/Nog Cells in Medical Conditions Affecting the Central Nervous System

Philadelphia

Myo/Nog cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (mAb). They are essential for eye development in the chick embryo and respond to injury in adult tissues. G8-positive Myo/Nog cells were present in the postnatal murine retina and they were a distinguished population from neuronal, Muller and microglial cells. In the neonatal retina, we observed the number of Myo/Nog cells increase, in numbers and location, parallel with cell death induced by oxygen-induced stress. Depletion of Myo/Nog cells lead to a substantial increase in cell death in the oxygen-induced retinopathy model. In a light damage model of retinopathy, external addition of purified Myo/Nog cell into the vitreous improved photoreceptor and inner retina neuronal function as measured by full field, flash electroretinogram (ERG). These results suggest that Myo/Nog cells preserve neuronal function from pathologically induced cell stress.