Involvement of inhibitory dopamine-2 receptors in resting bradycardia in exercise-conditioned rats

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The purpose of this investigation was to examine the underlying cause for the resting bradycardia and lower resting blood pressure demonstrated in conscious rats that performed 12 wk of treadmill exercise conditioning. The influence of inhibitory dopamine (DA2) receptors and α2-adrenoceptors, which are known to mediate bradycardia and hypotension, was assessed in exercise-conditioned (EC) and nonexercised conditioned (NC) rats. To accomplish this, preferential DA2 and α2-agonists and antagonists were administered at rest to conscious rats after they participated in an exercise conditioning program. The results obtained with the DA2 antagonist metoclopramide (15 mg/kg ip) alone suggest that there is physiological activation of cardiovascular DA2 receptors in EC rats but not in NC rats. Furthermore, the results obtained with the DA2 agonist bromocriptine (1.5 mg/kg ip) suggest that the DA2 receptor-mediated bradycardia and hypotension are greater in EC rats than in NC rats. In addition, heart rate and blood pressure responses to the α2-agonist clonidine (0.1 mg/kg ip) and antagonist yohimbine (1 mg/kg ip) were not different between EC and NC rats. These data suggest that enhanced DA2 receptor influence accounts, in part, for the resting bradycardia and lower resting blood pressure demonstrated in EC rats after 12 wk of exercise conditioning.

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Journal of applied physiology





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This article was published in Journal of applied physiology, Volume 74, Issue 5, Pages 2086-2091.

The published version is available at http://jap.physiology.org/content/74/5/2086 .

Copyright © 1993.

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