Location
Philadelphia, PA
Start Date
30-4-2025 1:00 PM
End Date
30-4-2025 4:00 PM
Description
Curcumin, a bioactive compound derived from turmeric (Curcuma longa), is widely recognized for its potential therapeutic properties, including anti-inflammatory, antioxidant, and anticancer effects. However, its clinical application is hindered by poor bioavailability, primarily due to low solubility, rapid metabolism, and poor systemic distribution. Nanoparticle-based delivery systems have emerged as a promising approach to overcome these challenges, offering enhanced stability, targeted delivery, and controlled release of curcumin.
This review evaluates the efficacy of nanoparticle-based curcumin delivery systems in improving bioavailability and therapeutic outcomes in human subjects. A systematic review of peer-reviewed studies from major literature databases was conducted. Inclusion criteria included the use of nanoparticles such as liposomes, polymeric nanoparticles, and solid lipid nanoparticles, among others. Outcomes assessed included curcumin plasma concentration, therapeutic efficacy, and safety profiles.
The results indicate an increase in curcumin bioavailability with nanoparticle-based formulations compared to conventional formulations. Several studies reported enhanced therapeutic outcomes, including improved anti-inflammatory markers, reduced oxidative stress, and better patient-reported outcomes in chronic diseases. The analysis also highlights variability in nanoparticle formulations, emphasizing the need for standardized methodologies to optimize delivery systems.
Embargo Period
5-29-2025
Included in
Enhancing Curcumin Bioavailability: A Systematic Review of Nanoparticle-Based Approaches
Philadelphia, PA
Curcumin, a bioactive compound derived from turmeric (Curcuma longa), is widely recognized for its potential therapeutic properties, including anti-inflammatory, antioxidant, and anticancer effects. However, its clinical application is hindered by poor bioavailability, primarily due to low solubility, rapid metabolism, and poor systemic distribution. Nanoparticle-based delivery systems have emerged as a promising approach to overcome these challenges, offering enhanced stability, targeted delivery, and controlled release of curcumin.
This review evaluates the efficacy of nanoparticle-based curcumin delivery systems in improving bioavailability and therapeutic outcomes in human subjects. A systematic review of peer-reviewed studies from major literature databases was conducted. Inclusion criteria included the use of nanoparticles such as liposomes, polymeric nanoparticles, and solid lipid nanoparticles, among others. Outcomes assessed included curcumin plasma concentration, therapeutic efficacy, and safety profiles.
The results indicate an increase in curcumin bioavailability with nanoparticle-based formulations compared to conventional formulations. Several studies reported enhanced therapeutic outcomes, including improved anti-inflammatory markers, reduced oxidative stress, and better patient-reported outcomes in chronic diseases. The analysis also highlights variability in nanoparticle formulations, emphasizing the need for standardized methodologies to optimize delivery systems.