Date of Award
Selective Evidence-Based Medicine Review
Master of Science in Health Sciences - Physician Assistant
Physician Assistant Studies
John Cavanagh, PhD, PA-C
Objective: The objective of this selective EBM review is to determine whether fixed-combination prostaglandin analog/β-blocker therapy is safe and more effective than β-blocker monotherapy in the prevention of disease progression in adults with open-angle glaucoma.
Study Design: Review of three English language randomized controlled trials published in 2008 and 2010.
Data sources: 3 randomized, controlled, double-blind trials comparing fixed-combination prostaglandin analog/β-blocker therapy to β-blocker monotherapy were found using Pubmed, Medline, and Cochrane databases.
Outcome Measured: Disease progression/regression was assessed by post-baseline measurement of IOP during three follow-up visits throughout the trials. The safety profile of each therapy was assessed by monitoring the number of adverse events reported by the participants or observed by the researchers.
Results: All three studies demonstrated a significantly greater IOP reduction in participants treated with fixed combination prostaglandin analog/β-blocker therapy. There was a significantly higher incidence of adverse events in the fixed combination group compared to the β-blocker monotherapy group; however, the fixed combination therapy was determined to be well-tolerated and superior over β-blocker monotherapy in the prevention of disease progression of open-angle glaucoma.
Conclusions: Fixed combination prostaglandin analog/β-blocker therapy is safe and more effective than β-blocker monotherapy in the prevention of disease progression in adults with open-angle glaucoma. The simple dosing schedule increases patient adherence compared to the more complex multi-drug regimen of the individual active components.
Pham, My-Hang, "Is Fixed-combination Prostaglandin Analog/β-blocker Therapy Safe and More Effective than β-blocker Monotherapy in the Prevention of Disease Progression in Adults with Open-angle Glaucoma?" (2012). PCOM Physician Assistant Studies Student Scholarship. 77.