Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies


Objective: The objective of this selective EBM review is to determine whether or not using “preoperative therapy can improve function in postoperative patients undergoing Total Knee Arthroplasty?”

Study Design: A review of three double-blinded randomized control trials (RCT) that were peered reviewed after 2014

Data Source: All articles were published in peer-reviewed journals and were researched using PubMed. Studies were selected based on their ability to answer the question posed in the objective, and if the researched outcomes were patient oriented.

Outcomes: Assessed outcomes were either from a Timed Up and Go test or Stair Climbing Test.

Results: Joaquin Calatayud et al. calculated a statistically significant p-value of <.0001 in comparing preoperative therapy with postoperative therapy compared to postoperative therapy alone. Pascale Gränicher et al. calculated a statistically insignificant p value<.984. Jose-Maria Blasco et al. showed a statistically significant p value<.0001.

Conclusions: Two RCTs showed significance based on the calculated p-value given. Preoperative training in combination with postoperative therapy results show evidence of improving function postoperatively. Future studies can work with a larger patient population alone with TENS units to speed neural networks recovery.