Date of Award
Selective Evidence-Based Medicine Review
Master of Science in Health Sciences - Physician Assistant
Physician Assistant Studies
Objective: The objective of this selective EBM review is to determine whether or not secukinumab is effective in improving physical function in patients with active psoriatic arthritis.
Study Design: Systematic review of three randomized controlled trials (RCTs) published between 2016 and 2017. All studies were published in the English language.
Data Sources: Three randomized controlled trials (RCTs) published in peer-reviewed journals comparing the efficacy of secukinumab as an injectable medication for improving physical function in patients with active psoriatic arthritis. All studies were found using PubMed and Alt HealthWatch.
Outcomes Measured: In all three studies, improvement in physical function in patients with active psoriatic arthritis was measured using the Health Assessment Questionnaire Disability Index (HAQ-DI).
Results: All three studies demonstrated improvement in physical function in patients with active PsA with the use of secukinumab versus the control group. Kavanaugh et al. (Arthritis Care Res (2151464X). 2017;69(3):347-355. doi: 10.1002/acr.23111.) reported a mean change from baseline of approximately -0.4 in both treatment groups (150 mg and 75 mg) and a mean change from baseline of -0.17 in the comparison placebo group. Strand et al. (Ann Rheum Dis. 2017;76(1):203-207. doi: 10.1136/annrheumdis-2015-209055 [doi]) reported a mean change from baseline of -0.40 in those receiving 150 mg, -0.41 in those receiving 75 mg and -0.17 in those receiving a placebo. McInnes et al. (Rheumatology (Oxford). 2017;56(11):1993-2003. doi: 10.1093/rheumatology/kex301 [doi]) reported a mean change from baseline of -0.48 in the group receiving 150 mg and -0.32 in the group receiving 0.75 mg compared to -0.31 in the placebo group.
Conclusions: According to all three studies, secukinumab was found to be effective in improving physical function in patients with active psoriatic arthritis. Further studies are recommended.
Krawiec, Ania M., "Is Secukinumab Effective in Improving Physical Function in Patients with Active Psoriatic Arthritis?" (2020). PCOM Physician Assistant Studies Student Scholarship. 529.