Date of Award
Selective Evidence-Based Medicine Review
Master of Science in Health Sciences - Physician Assistant
Physician Assistant Studies
Laura Levy, DHSc, PA-C
OBJECTIVE: The objective of this selective EBM review is to determine whether or not using the LigaSure device provides any benefit in morality in patients undergoing hepatic resection surgery.
STUDY DESIGN: Review of three English language randomized control trials published in 2007, 2009 and 2012.
DATA SOURCES: Data sources obtained for this review primary studies published in peerreviewed journals, found using PubMed.
OUTCOMES MEASURED: Patient mortality, defined as death within 30 days of the surgical procedure.
RESULTS: The study done by Doklestic and et al had 3 patient mortalities occur. The deaths occurred on post op days three, four and nine and were due to pulmonary embolism, acute myocardial infarction and heart failure, respectively.8 Zero mortalities occurred in the remaining two studies.9,10
CONCLUSIONS: The results of the studies showed that LigaSure did not provide a benefit in mortality compared to the clamp crushing method, the cavitron ultrasonic surgical aspirator (CUSA) method and to ultrasonic shears.
Kleiber, Samantha M., "Does the LigaSure Vessel Sealing System Provide Benefit in Mortality in Regards to Hepatic Resections?" (2019). PCOM Physician Assistant Studies Student Scholarship. 443.