Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

Laura Levy, DHSc, PA-C


OBJECTIVE: The objective of this selective EBM review is to determine whether or not Methylcobalamin alone or in combination with Lidocaine is clinically more effective than Lidocaine alone in relieving Herpes Zoster related neuropathic pain with subcutaneous injections.

STUDY DESIGN: This is a systematic review of three peer-reviewed primary studies. All were randomized, controlled trials published between the years of 2014 and 2016.

DATA SOURCES: Data sources obtained for this review were published in peer reviewed journals and selected from PubMed Database.

OUTCOME MEASURED: The outcomes measured reflected the effectiveness of incorporating subcutaneous Methylcobalamin in the treatment regimen for neuropathic pain in Herpes Zoster patients. The patients in each study reported their pain at baseline and after treatment using an 11-point NRS to assess a significant change in pain.

RESULTS: All three studies conducted showed significant improvement in Herpes Zoster related neuropathic pain for the participants whose treatment regimen included subcutaneous Methylcobalamin injections.

CONCLUSIONS: The evidence presented in this review is conclusive that the use of subcutaneous injections of Methylcobalamin in the treatment of Herpes Zoster related neuropathic pain is significantly more effective than Lidocaine alone.

Included in

Neurology Commons