Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

Laura Levy, DHSc, PA-C


Objective: The objective of this selective EBM review is to determine whether or not “Does metacognitive training (MCT) improve the quality of life in patients with schizophrenia?”

Study Design: Systematic review of three randomized controlled trials (RCTs) published in peer-reviewed journals between 2010-2014, all in the English language; two of which were published in 2014 and one in 2010.

Data Sources: Three randomized controlled trials found using PubMed.

Outcomes Measured: Quality of life with a focus on social relationships was assessed using the Brief Quality of Life Questionnaire of the World Health Organization (WHOQOL-BREF) or Quality of Life Scale (QLS).

Results: Briki et al. showed an improvement in the social initiatives variable on the QLS after MCT compared to the control group consisting of Supportive therapy (ST) and antipsychotic medications, however, data was not statistically significant (p-value >0.05). Moritz et al. 2010 showed statistically significant improvement in social functioning after MCT compared to the control of treatment as usual (p-value = 0.03). Moritz et al. 2014 also showed an improvement in quality of life regarding the social variable when compared to the control of COGPACK + antipsychotic medications, however, the results were not statistically significant (p-value = 0.16).

Conclusion: The articles analyzed in this EBM review claim MCT improves quality of life in patients with schizophrenia. Evidence from these studies are inconclusive on whether MCT improves social aspect of quality of life in patients with schizophrenia. Further studies incorporating larger sample size, sufficiently longer reassessment duration, and the effects of MCT on schizophrenia with comorbid substance abuse, are needed in order to determine the validity of MCT on improvement of quality of life in patients with schizophrenia.