Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


Objective: The objective of this evidence based medicine review is to determine whether or not soy-based proteins, meals, and diets are effective treatments in reducing waist circumference in overweight and obese adults ages 20-75 years.

Study design: Review of three published, randomized controlled trials (RCTs) published in 2003, 2007, and 2011. All English language.

Data Source: The three randomized controlled trials that used in this review were found using PubMed.

Outcomes measured: The outcomes measured were improvement of patient’s overweight and obesity status and their overall quality of life through the indication of reduced waist circumference. By measuring patient’s waist circumference before, during, and after treatment of soy-based proteins, meals, and diets with measurement methods between the lower rib and iliac crest at the level of the navel, a non-distensible tape measure, and an inelastic scale.

Results: In a RCT by Allison et al. (2003), soy-based meal replacement formula reduced waist circumference for overweight and obese adults in a 12 weeks period with an estimate treatment effectiveness of P

Conclusions: The result of all three randomized controlled trials suggest that soy-based proteins, meals, and diets, as a form of treatment for reduction in waist circumference is effective in regards of patient’s overweight and obesity status and their overall quality of life. This topic does warrant additional research. Further studies conducted should include if patient needs a post-life-long maintain diet with soy-based proteins and meals after they have achieve a normal BMI waist circumference. In addition, will this be available for patients with mild soy-allergy, but controlled with anti-histamines.