Date of Award
Selective Evidence-Based Medicine Review
Master of Science in Health Sciences - Physician Assistant
Physician Assistant Studies
John Cavenagh, MBA, PhD, PA-C
OBJECTIVE: The objective of this selective EBM review is to determine whether or not ceramide containing creams are a safe and effective treatment for patients with atopic dermatitis.
STUDY DESIGN: Review of three randomized controlled studies published in English between 2009-2016.
DATA SOURCES: Three assessor blind randomized controlled trials found using PubMed and EbscoHOST databases.
OUTCOMES MEASURED: Each of the three trials assessed safety and efficacy of a ceramide containing cream compared with another method in the treatment of atopic dermatitis. Outcomes were measured by Eczema Severity Score (ESS), rating of skin dryness on a 0-4 scale, transepidermal water loss (TEWL) measurements, and Severity Scoring for Atopic Dermatitis (SCORAD) on a scale of 0-72.
RESULTS: The Marseglia et al1 study showed that subjects using the ceramide containing cream had an 84% reduction in their Eczema Severity Score (ESS), compared to the subjects using the simple hydrating cream who had a 50% reduction in the ESS. This difference was statistically significant as p=0.0001. The Simpson et al2 study showed statistically significant improvements in skin dryness, skin hydration and transepidermal water loss (TEWL) in the cream with a ceramide precursor as compared to no treatment. The Sugarman et al3 study showed a 50.7% decrease (p
Francis, Jennifer M., "Are Ceramide Containing Creams A Safe And Effective Treatment For Patients With Atopic Dermatitis?" (2017). PCOM Physician Assistant Studies Student Scholarship. 392.