Date of Award

2017

Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant

Department

Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C

Abstract

OBJECTIVE: The objective of this selective EBM review is to determine whether or not ceramide containing creams are a safe and effective treatment for patients with atopic dermatitis.

STUDY DESIGN: Review of three randomized controlled studies published in English between 2009-2016.

DATA SOURCES: Three assessor blind randomized controlled trials found using PubMed and EbscoHOST databases.

OUTCOMES MEASURED: Each of the three trials assessed safety and efficacy of a ceramide containing cream compared with another method in the treatment of atopic dermatitis. Outcomes were measured by Eczema Severity Score (ESS), rating of skin dryness on a 0-4 scale, transepidermal water loss (TEWL) measurements, and Severity Scoring for Atopic Dermatitis (SCORAD) on a scale of 0-72.

RESULTS: The Marseglia et al1 study showed that subjects using the ceramide containing cream had an 84% reduction in their Eczema Severity Score (ESS), compared to the subjects using the simple hydrating cream who had a 50% reduction in the ESS. This difference was statistically significant as p=0.0001. The Simpson et al2 study showed statistically significant improvements in skin dryness, skin hydration and transepidermal water loss (TEWL) in the cream with a ceramide precursor as compared to no treatment. The Sugarman et al3 study showed a 50.7% decrease (p

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