Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


Objective: The objective of this selective EBM review is to determine whether or not Integra® improves patient scar quality compared to standard autograft-allograft technique or splitthickness skin graft (STSG).

Study Design: Selective EBM review of two randomized controlled trials and one retrospective study.

Data Sources: All studies were published in peer-reviewed journals found on PubMed.

Outcome(s) measured: The main outcome measured is patient scar quality, further defined by scar pigmentation, pliability, height, irregularity, vascularity, range of movement, softness, appearance, sensation, dryness, itch, and sweating.

Results: The study by Lagus, et al found that STSG had better scar outcomes than Integra® in 12 months. On the contrary, Branski, et al found a significant improvement in scars with the use of Integra® at both 12 months and 18-24 months post burn injury. The study by Moiemen, et al also showed statistical improvement in patient scars with Integra® two or more years after treatment.

Conclusions: The three studies evaluated in this EBM review have conflicting results. Further research is warranted to evaluate whether Integra® improves patient scar quality compared to STSG.