Date of Award
Selective Evidence-Based Medicine Review
Master of Science in Health Sciences - Physician Assistant
Physician Assistant Studies
John Cavenagh, MBA, PhD, PA-C
Objective: The objective of this selective EBM review is to determine whether or not the use of oral amphetamines reduces cocaine use in cocaine-dependent individuals.
Study Design: Review of three English language randomized control trials (RCTs) published in 2001, 2003 and 2004.
Data Sources: 3 randomized controlled trials published after 1999 were obtained using PubMed, OVID, and Medline.
Outcomes Measured: The efficacy of using d-amphetamine to promote cocaine use cessation in cocaine-dependent individuals, determined using immunoassay and mass spectrometric analysis to identify cocaine metabolites in the participant’s urine.
Results: Grabowski et al (2004) found a significant reduction in the use of cocaine in cocaine-dependent individuals, while Grabowski et al (2001) and Shearer et al were unable to show a significant reduction.
Conclusion: Evidence supporting the role of oral amphetamines in reducing cocaine use in cocaine-dependent individuals is inconclusive and conflicting at this time. However, further research and larger scale analysis is warranted and feasible considering the suggestive outcomes these studies represent.
Strate, Kevin M., "Does the Use of Oral Amphetamines Reduce Cocaine Use in Cocaine-Dependent Individuals?" (2016). PCOM Physician Assistant Studies Student Scholarship. 301.