Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


OBJECTIVE: The objective of this EBM review is to determine whether or not a daily vitamin supplement is effective treatment for recurrent aphthous ulcers.

STUDY DESIGN: A review of 3 randomized control trials. All three trials are in English between 2009-2014.

DATA SOURCES: 3 randomized double blind placebo-controlled parallel-arm single center trials were found using PubMed.

OUTCOMES MEASURED: Each of the RCTs measured the efficacy of treatment for RAU in patients with aphthous ulcer outbreaks for at least a year or at least one to three outbreaks a month. This was performed by subjects of the study reporting on efficacy of each a daily multivitamin, Omega-3 supplement or Vitamin B12 supplement following the recommended daily intake scale.

RESULTS: All three RTCs were used in this review and it was determined that a daily vitamin supplement did not lead to any significant life-threatening conditions.

CONCLUSIONS: Based on the three trials, only the multivitamin supplement proved to be ineffective in the treatment of recurrent aphthous ulcers in adults. Both the Omega-3 and Vitamin B12 proved to be both cost-effective and improved the quality of life for patients with RAU.