Date of Award
Selective Evidence-Based Medicine Review
Master of Science in Health Sciences - Physician Assistant
Physician Assistant Studies
John Cavenagh, MBA, PhD, PA-C
OBJECTIVE: The objective of this selective EBM review is to determine whether or not lubiprostone is effective in treating symptoms of chronic constipation.
STUDY DESIGN: Review of three English language primary randomized controlled trials from 2007- 2010.
DATA SOURCES: Three double-blind, randomized, controlled trials were found using PubMed. These studies compared treatment with lubiprostone to a visually matched placebo.
OUTCOME MEASURED: The frequency of each patient’s spontaneous bowel movements within the first 24 hours after initial treatment was recorded from the data collected from the patient’s daily diary.
RESULTS: All three trails demonstrated a statistically significant improvement in the rates of spontaneous bowel movements in patients with chronic constipation receiving treatment with lubiprostone compared to those receiving the placebo.
CONCLUSIONS: Based on theses three trials, lubiprostone is effective in treating symptoms of chronic constipation.
MacDonald, Christine M., "Is Lubiprostone Effective in Treating Symptoms of Chronic Constipation?" (2015). PCOM Physician Assistant Studies Student Scholarship. 236.