Date of Award


Degree Type

Selective Evidence-Based Medicine Review

Degree Name

Master of Science in Health Sciences - Physician Assistant


Physician Assistant Studies

Department Chair

John Cavenagh, MBA, PhD, PA-C


Objective: The objective of this selective EBM review is to determine whether or not there is efficacy with combination treatment benzoyl peroxide and clindamycin for progressive macular hypomelanosis in adults.

Study Design: A review of three English language studies. One published in 2006 and two in 2011. Includes two RCT’s and one randomized left-right comparison study.

Data Sources: Researched articles via PubMed and Cochrane database. All articles were published in peer-reviewed journals. Two randomized, controlled trials and one randomized left-right comparison study were used.

Outcomes Measured: The outcomes measured by: subjective patient ratings based on photographs before and after treatment and two dermatologists’ ratings. Relyveld et al study and Sim et al study in addition used a color analyzer.

Results: The two randomized, controlled trials and the left-right comparison study showed that the use of clindamycin and benzoyl peroxide was effective in the treatment of progressive macular hypomelonosis in adults. Results from these three studies showed Improvement of the overall PMH lesions by the investigator, patient, dermatologist and color analyzer (quantitatively compares discoloration, erythema, pigmentation and skin color).

Conclusions: The results of the randomized, controlled trials and left-right comparison study indicate that combination products clindamycin and benzoyl peroxide are effective in the treatment of progressive macular hypomelonosis. All three studies also demonstrated that benzoyl peroxide and clindamycin were safe when used to treat PMH.