The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.

The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.

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Submissions from 2012

The preformulation stability studies of a proline prodrug of methotrexate, Ann Stephenson, Zhiqian Wu, and Xudong Yuan

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NLRP3 Inflammasome is a Target for Development of Broad-Spectrum Anti-Infective Drugs, James D. Thacker, Brian J. Balin, Denah M. Appelt, Sihem Sassi-Gaha, Mitali Purohit, Richard F. Rest, and Carol M. Artlett

On researching the agency of youth: Moving beyond traditional theorizing. Commentary on Nsamenang, Celine I. Thompson

In vivo iontophoretic delivery of salmon calcitonin across microporated skin, Viswatej Vemulapalli, Yun Bai, Haripriya Kalluri, Anushree Herwadkar, Hyun Kim, Shawn P. Davis, Phil M. Fridin, and Ajay K. Banga

Streamlining Undergraduate Medical Education: Something We Should Have Discussed Decades Ago, Mark Vila

The West Virginia Prescription Drug Abuse Quitline: Challenges and Lessons Learned from Running a Remote Quitline, Rebecca J. White, Keith J. Zullig, Laura Lander, Clara Shockley, Robert Pack, and Carl Sullivan

Cooperative roles of BDNF expression in neurons and schwann cells are modulated by exercise to facilitate nerve regeneration, J. C. Wilhelm, Mei Xu, D. Cucoranu, S. Chmielewski, T. Holmes, K. S. Lau, G. J. Bassell, and A. W. English

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Cooperative Roles of BDNF Expression in Neurons and Schwann Cells are Modulated by Exercise to Facilitate Nerve Regeneration, Jennifer C. Wilhelm, Mei Xu, Delia Cucoranu, Sarah E. Chmielewski, Tiffany M. Holmes, Kelly S. Lau, Gary J. Bassell, and Arthur W. English

Non-Invasive Ventilation and Gastrostomy May Not Impact Overall Quality of Life in Patients with ALS, Kristen Zamietra, Erik B. Lehman, Stephanie H. Felgoise, Susan M. Walsh, Helen E. Stephens, and Zachary Simmons

Non-invasive ventilation and gastrostomy may not impact overall quality of life in patients with ALS, Kristen Zamietra, Erik B. Lehman, Stephanie S. Felgoise, Helen E. Stephens, and Zachary Simmons

Allergic reaction to peripheral nerve stimulator, L. Zhou, A. Lee, R. Schaffner, and Gerald E. Dworkin

Submissions from 2011

Oseltamivir use in psychiatric inpatients taking clozapine: effect on neuropsychiatric events, Shari N. Allen, Tammie Lee Demler, Eileen Trigoboff, and Lewis A. Opler

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of a7*nAChR function, Tanguy Araud, Sharon Graw, Ralph Berger, Michael Lee, Estele Neveu, Daniel Bertrand, and Sherry Leonard

Effect of resveratrol on fat mobilization, Clifton A. Baile, Jeongyeh Yang, Srujana Rayalam, Diane L. Hartzell, Chingyi Lai, Charlotte Andersen, and Mary Anne Della-Fera

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Evidence for an Infectious Etiology in Alzheimer's Disease, Brian J. Balin PhD, Christine Hammond, C. Scott Little PhD, Denah Appelt, and Susan Hingley

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Analysis of Chlamydia pneumoniae-infected monocytes following incubation with a novel peptide, acALY18, implicates the inflammasome in clearance of infection, Brian J. Balin, James D. Thacker, Charles Lim, Corey M. Caruthers, Susan T. Hingley, Juliana Zoga, and Denah M. Appelt

Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice, Shoshana M. Bartell, Srujana Rayalam, Suresh Ambati, Dhanunjaya Gaddam, Diane L. Hartzell, Mark Hamrick, Jinxiong She, Mary Anne Della-Fera, and Clifton A. Baile

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Analysis of Chlamydia pneumoniae and AD-like Pathology in the Brains of BALB/c Mice Following Direct Intra-cranial Infection, Jessica Rachel Barton, Christine J. Hammond, Amy L. Brady, Denah M. Appelt, Brian J. Balin, and Christopher Scott Little

MRSA Otorrhea: A Case Series and Review of the Literature, Katherine M. Baugher, Troy Sommers Hemme, Mary Hawkshaw, and Robert T. Sataloff

Flawed science is not evidence-based osteopathic medicine, Murray R. Berkowitz

Increasing the number of osteopathic graduate medical education programs-"The time has come", Murray R. Berkowitz

Osteopathic scholarship, research and publication, Murray R. Berkowitz

Bipolar Affective Disorder in Young People: A Review, Bettina Bernstein

Secretory phospholipase A 2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2, Vishakha Bhave, Shashikiran Donthamsetty, John R. Latendresse, Michael L. Cunningham, and Harihara M. Mehendale

Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo, Vishakha Bhave, Shirish Paranjpe, William C. Bowen, Shashikiran Donthamsetty, Aaron W. Bell, Jaspal S. Khillan, and George K. Michalopoulos

A novel microparticulate vaccine for melanoma cancer using transdermal delivery, Tuhin Bhowmik, Bernadette D'Souza, Rangaiah Shashidharamurthy, Carl Oettinger, Periasamy Selvaraj, and Martin D'Souza

RhoB Deficiency in Thymic Medullary Epithelium Leads to Early Thymic Atrophy, Arturo Bravo Nuevo, Rebekah O'Donnell, Alexander Rosendahl, Jae Hoon Chung, Laura E Benjamin, and Chikako Odaka

RhoB Loss Prevents Streptozotocin-induced Diabetes and Ameliorates Diabetic Complications in Mice, Arturo Bravo Nuevo, Hikaru Sugimoto, Seema Iyer, Zachary Fallon, Jason M Lucas, Shiva Kazerounian, George C Prendergast, Raghu Kalluri, Nathan I Shapiro, and Laura E Benjamin

Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China, Hanchun Chen, H. Chen, Md. Asaduzzaman Khan, Zhouzhou Rao, Xinxing Wan, Bo Tan, and Dianzheng Zhang

Osteopathic approach to a patient with chronic fatigue syndrome, Anne Chong and Murray R. Berkowitz

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Modulation of Myocardial Mitochondrial Mechanisms during severe Polymicrobial Sepsis in the Rat, M. Chopra, H. B. Golden, S. Mullapudi, W. Dowhan, D. E. Dostal, and Avadhesh C. Sharma

Mechanisms involved in apoptosis events contributing to sepsis-induced myocardial dysfunction, M. Chopra and Avadhesh C. Sharma

The synarcual cartilage of batoids with emphasis on the synarcual of Rajidae, Kerin M. Claeson

The skeleton | Cartilaginous Fish Skeletal Anatomy, Kerin M. Claeson and M. N. Dean

Morphology of the anterior vertebral region in elasmobranchs: Special focus, Squatiniformes, Kerin M. Claeson and A. Hilger

Youth Gangs: Reason for Concern, Paul Thomas Clements and Cliff Akiyama

Psychological Health in Patients with ALS is Maintained as Physical Function Declines, Julia Cupp, Zachary Simmons, Arthur Berg, Stephanie H. Felgoise, Susan M. Walsh, and Helen E. Stephens

Nutrition in Medical Education: History, Current Status, and Resources, Farzaneh Daghigh, David J. Vettori, and Jeffrey Harris

Vitamins, Michael J. Deimling

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Infection of neuronal cells by Chlamydia pneumoniae and Herpes simplex virus type 1 alters expression of genes associated with Alzheimer’s disease, Morgan M. Devins, Fiora D. Zoga, Brian J. Balin, Denah M. Appelt, and Susan T. Hingley

Demystifying the Millennial Student: A Reassessment in Measures of Character and Engagement in Professional Education, Camille DiLullo, Patricia McGee, and Richard M. Kriebel

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Limited Availability of ZB P1 Restricts Axonal mRNA Localization and Nerve Regeneration Capacity, Christopher J. Donnelly, Dianna E. Willis, Mei Xu, Chhavy Tep, Chunsu Jiang, Soonmoon Yoo, N. Carolyn Schanen, Catherine B. Kirn-Safran, Jan van Minnen, Arthur English, Sung Ok Yoon, Gary J. Bassell, and Jeffery L. Twiss

Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity, C. J. Donnelly, D. E. Willis, Mei Xu, C. Tep, C. Jiang, and et al.

Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene, Shashikiran Donthamsetty, Vishakha Bhave, Corrine S. Kliment, William C. Bowen, Wendy M. Mars, Aaron W. Bell, Rachel E. Stewart, Anne Orr, Chuanyue Wu, and George K. Michalopoulos

Changes in Self-Reported Drinking Behaviors among US Teenagers Associated with the Introduction of Flavored Malt Beverages: An Interrupted Time Series Quasi-experiment, Jane Z. Dumsha, Robert A. DiTomasso, Frank C. Gomez, Nancy J. Melucci, and Bruce C. Stouch

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In the Ether, Out of View: Cyberbullying and Suicide Risk, Terri A. Erbacher PhD

Do research intermediaries reduce perceived coercion to enter research trials among criminally involved substance abusers?, David Festinger, K. Dugosh, J. Croft, P. Arabia, and D. Marlowe

Optimizing Outcomes for GLP-1 Agonists, Jeffrey S. Freeman

Review of Swedenborg’s Paradigm of the Brain, David B. Fuller

Robert C. Fulford, D.O., David B. Fuller

Care at the Close of Life: Evidence and Experience, Katherine E. Galluzzi

Sexuality as Women Age, Katherine E. Galluzzi

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells, P. S. Ganapathy, Richard E. White, Y. Ha, Bozard B. Renee, P. L. McNeil, Caldwell R. William, S. Kumar, S. M. Black, and S. B. Smith

Retrieval of Inferior Vena Cava Filters after Prolonged Indwelling Time, Franklin Garcia-Godoy, Tara Collins, David Sacks, Steve Vasas, and Babak Sarani

Myo/Nog Cell Regulation of Bone Morphogenetic Protein Signaling in the Blastocyst Is Essential for Normal Morphogenesis and Striated Muscle Lineage Specification, Jacquelyn Gerhart, Victoria L Scheinfeld, Tara Milito, Jessica Pfautz, Christine Neely, Dakota Fisher-Vance, Kelly Sutter, Mitchell Crawford, Karen Knudsen, and Mindy George-Weinstein

Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specification, Jacquelyn Gerhart, V. Scheinfeld, T. Milito, J. Pfautz, C. Neely, C. Fisher-Vance, K. Sutter, M. Crawford, K. Knudsen, and Mindy George-Weinstein

Self-Assessed Learning Style Correlates to use of Supplemental Learning Materials in an Online Course Management System., Caitlin Halbert, Richard M. Kriebel, Robert Cuzzolino, Patrick Coughlin, and Kerin Fresa-Dillon

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Understanding the impact of limb loss in veterans., K. Haldaman and Scott D. Glassman

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Facilitating School Reintegration for Children with Traumatic Brain Injury, James B. Hale, Nadine Metro, Jessica Glass Kendorski, Lisa A. Haim, James Whitaker, and Jaime Moldovan

Executive Impairment Determines ADHD Medication Response: Implications for Academic Achievement, James B. Hale, Linda A. Reddy, Margaret Semrud-Clikeman, Lisa A. Hain, James Whitaker, Jessica Morley, Kyle Lawrence, Alex Smith, and Nicole Jones

Financial Analysis in Pharmacy Practice, Keith N. Herist, Brent Rollins, and Matthew Perri

Tethered antibiotics, N. J. Hickok, C. Ketonis, and Christopher S. Adams

Tethered Antiobiotics, N. J. Hickok, C. Ketonis, and Christopher S. Adams

Implementation of a Stroke Alert Protocol in the Emergency Department: A Pilot Study, Carl Hoegerl, Frederick J. Goldstein, and Jennifer Sartorius

Homologous expression of a subcomplex of pyrococcus furiosus hydrogenase that interacts with pyruvate ferredoxin oxidoreductase, R. C. Hopkins, J. Sun, Francis E. Jenney Jr., S. K. Chandrayan, P. M. Mcternan, and M. W. Adams

Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain., Kirsten Hoyer, Yejia Song, Desuo Wang, Dillon Phan, James Balschi, Joanne S Ingwall, Luiz Belardinelli, and John C Shryock

To the Point: Medical Education Reviews-Ongoing Call for Faculty Development, Nancy A. Hueppchen, John L. Dalrymple, Maya M. Hammoud, Jodi F. Abbott, Petra M. Casey, Alice W. Chuang, Amie J. Cullimore, Katrina R. Davis, Lorraine Dugoff, Eve L. Espey, Joseph M. Kaczmarczyk, Francis S. Nuthalapaty, Edward Peskin, Archana Pradhan, and Nadine T. Katz

To the point: Medical education reviewsongoing call for faculty development, N. Hueppchen, J. L. Dalrymple, M. M. Hammoud, J. F. Abbott, P. M. Casey, A. W. Chuang, A. Cullimore, K. R. Davis, Joseph M. Kaczmarczyk, and et al.

Sacroiliac joint sparing in a patient with ankylosing spondylitis - An osteopathic approach, Joy Ishii, W. C. Ehrenfeuchter, K. M. Olds, and Murray R. Berkowitz

Eruptive Kaposi Sarcoma: An Unusual Presentation in an HIV-Negative Patient, Mollie M. Jan, Joseph W. Laskas, and Thomas D. Griffin

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Vancomycin Bonded to Bone Grafts Prevents Bacterial Colonization, Constantinos Ketonis, Stephanie Barr, Christopher S. Adams, Irving M. Shapiro, Javad Parvizi, and Noreen J. Hickok

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Antibacterial Activity of Bone Allografts: Comparison of a New Vancomycin-Tethered Allograft with Allograft Loaded with Adsorbed Vancomycin, Constantinos Ketonis, Stephanie Barr, Irving M. Shapiro, Javad Parvizi, Christopher S. Adams, and Noreen J. Hickok

Anticancer activities of Nigella sativa (Black Cumin), Md. Asaduzzaman Khan, Hanchun Chen, Mousumi Tania, and Dianzheng Zhang

Medicinal chemistry and the pharmacy curriculum., M O Faruk Khan, Michael J. Deimling, and Ashok Philip

Preventing bone loss and weight gain with combinations of vitamin d and phytochemicals, Chingyi Lai, Jeongyeh Yang, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Richard D. Lewis, Mark W. Hamrick, Diane L. Hartzell, and Clifton A. Baile

Infantile Melanoma-A Triple Threat: Diagnosis and Management, Milena Lambie, Chad Nadler, Paul Glat, Scott Van Duzer, Gregory Halligan, and Evan Geller

A Computational Framework for Proteome-Wide Pursuit and Prediction of Metalloproteins Using ICP-MS and MS/MS Data, W. Andrew Lancaster, Jeremy L. Praissman, Farris L. Poole, Aleksandar Cvetkovic, Angeli Lal Menon, Joseph W. Scott, Francis E. Jenney, Michael P. Thorgersen, Ewa Kalisiak, Junefredo V. Apon, Sunia A. Trauger, Gary Siuzdak, John A. Tainer, and Michael W. W. Adams

Relationship between standardized patient checklist item accuracy and performing arts experience, E. E. Langenau, D. J. Dowling, C. Dyer, and W. L. Roberts

The challenges for physicians of demonstrating continuing competence in the changing world of medical regulation: Osteopathic pediatrician case report, E. E. Langenau and J. R. Gimpel

Competency-based classification of COMLEX-USA cognitive examination test items, E. E. Langenau, G. Pugliano, and W. Roberts

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Relationships Between High-Stakes Clinical Skills Exam Scores and Program Director Global Competency Ratings of First-Year Pediatric Residents, E. E. Langenau, G. Pugliano, and W. L. Roberts

Pass/fail patterns of candidates who failed COMLEX-USA level 2-PE because of misrepresentation of clinical findings on postencounter notes, E. E. Langenau and J. M. Sandella

How soon can I play after a concussion?, Kate Laramie and Gretchen Fox

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Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse, Sanford Levine, Chhanda Biswas, Jamil Dierov, Robert J. Barsotti, Joseph B. Shrager, Taitan Nguyen, Seema Sonnad, John C. Kucharchzuk, Larry R. Kaiser, Sunil Singhal, and Murat T. Budak

Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse, S. Levine, C. Biswas, J. Dierov, Robert J. Barsotti, J. B. Shrager, T. Nguyen, S. Sonnad, J. C. Kucharchzuk, L. R. Kaiser, and et.al

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HElp3 directly modulates the expression of HSP70 gene in HeLa cells via HAT activity, Fen Li, Jixian Ma, Yu Ma, Yanyan Hu, Shuhuan Tian, Richard E. White, and Guichun Han

Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice, Chihwen Lin, Wendy M. Mars, Shirish Paranjpe, Shashikiran Donthamsetty, Vishakha Bhave, Liangi Kang, Anne Orr, William C. Bowen, Aaron W. Bell, and George K. Michalopoulos

Natural competence in the hyperthermophilic archaeon Pyrococcus furiosus facilitates genetic manipulation: Construction of markerless deletions of genes encoding the two cytoplasmic hydrogenases, G. L. Lipscomb, K. Stirrett, G. J. Schut, F. Yang, Francis E. Jenney Jr., R. A. Scott, M. W. Adams, and J. Westpheling

Identification of Heptapeptides Interacting with IFN-α-Sensitive CML cells, Jia Liu, Hanchun Chen, Zhou-zhou Rao, Md. Asaduzzaman Khan, Xin-Xing Wan, Ai-hua Xu, Nuo Zhang, and Dianzheng Zhang

Genetic Polymorphisms of Metabolic Enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and Gastric Carcinoma Susceptibility, Ya-Ping Luo, Hanchun Chen, Md. Asaduzzaman Khan, Fang-Zhi Chen, Xin-Xing Wan, Bo Tan, Fang-Dan Ou-Yang, and Dianzheng Zhang

Targeting dispositions for drug-involved offenders: A field trial of the Risk and Needs Triage (RANT)â„¢, D. Marlowe, David Festinger, and K. Dugosh

Matching consequences to behavior: Implications of failing to distinguish between noncompliance and nonresponsivity, J. Matejkowski, David Festinger, L. Benishek, and K. Dugosh

Feeding Mechanics and Dietary Implications in the Fossil Sloth Neocnus (Mammalia: Xenarthra: Megalonychidae) from Haiti, Robert McAfee

Rehabilitation of the Pelvis and the Sacroiliac Joint, Darren McAuley

Applying a multilevel interpretive framework with an emphasis on the assessment of executive functions, George McCloskey

Evaluating students with emotional and behavioral concerns, Barry L. McCurdy, Amanda L. Lannie, and Jennifer L. Jeffrey-Pearsall

Neuropsychology of auditory processing disorders, Mark R. McGowan, George McCloskey, Art Maerlender, and James Whitaker

Detection, advice, and referral to services (DARTS) procedures among clients with public defenders, A Mericle, S. Belenko, and David Festinger

Dynamics of the [4Fe-4S] cluster in pyrococcus furiosus D14C ferredoxin via nuclear resonance vibrational and resonance raman spectroscopies, force field simulations, and density functional theory calculations, D. Mitra, V. Pelmenschikov, Y. Guo, D. A. Case, H. Wang, W. Dong, M. Tan, T. Ichiye, Francis E. Jenney Jr., and et al.

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SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA, Heather L. Montie, Richard G. Pestell, and Diane E. Merry