The Philadelphia College of Osteopathic Medicine has a rich history of research, scholarship and publication, encompassing the case reports and reviews in the early Digests, the more formally presented articles in the College of Osteopathy's first research journal, Osteopathic Medicine, and current publications in some of the medical and pharmacology fields' leading peer-reviewed journals.
The PCOM Scholarly Papers repository is an archive for pre-publication drafts or final versions of research and editorial articles, abstracts, posters, and unpublished work by faculty and scientists at PCOM's Philadelphia and Georgia campuses.
Submissions from 2007
Covalently attached vancomycin provides a nanoscale antibacterial surface, V. Antoci Jr., Christopher S. Adams, J. Parvizi, P. Ducheyne, I. M. Shapiro, and N. J. Hickok
Vancomycin covalently bonded to titanium alloy prevents bacterial colonization, V. Antoci Jr., S. B. King, B. Jose, J. Parvizi, A. R. Zieger, E. Wickstrom, T. A. Freeman, R. J. Composto, Christopher S. Adams, and et al.
A Review of Cretaceous dipnoans from Argentina (Sarcopterygii Dipnoi) with Descriptions of New Species, Sebastian Apasteguia, Federico L. Agnolin, and Kerin M. Claeson
Inhibition of Apoptosis in Neuronal Cells Infected with Chlamydophila (Chlamydia) pneumoniae, Denah M. Appelt, Maria Roupas, Deana Way, Marcus G. Bell, Elizabeth V. Albert, Christine J. Hammond, and Brian J. Balin
HIF-1 Regulation of Chondrocyte Apoptosis: Induction of the Autophagic Pathway, J. Bohensky, I. M. Shapiro, S. Leshinsky, S. P. Terkhorn, Christopher S. Adams, and V. Srinivas
Decision analysis model evaluating the cost-effectiveness of risperidone, olanzapine and haloperidol in the treatment of schizophrenia, Mark Bounthavong and Mark P. Okamoto
Relationship Between Mitochondrial DNA Damage and Photoreceptor Death in Developing and Adult Retina, Assessed in Normal and Degenerative Rat Strains, Arturo Bravo Nuevo, Neal K Williams, Krisztina Valter, and Jonathan Stone
The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis, M. A. Bucaro, A. M. Zahm, M. V. Risbud, P. S. Ayyaswamy, K. Munkundakrishnan, M. J. Steinbeck, I. M. Shapiro, and Christopher S. Adams
The first agmatine/cadaverine aminopropyl transferase: Biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon Pyrococcus furiosus, G. Cacciapuoti, M. Porcelli, M. Moretti, F. Sorrentino, L. Concilio, V. Zappia, Z. Liu, W. Tempel, Francis E. Jenney Jr., and et al.
Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons, Qian Chen and H. L. Pan
Apoptotic cardiomyocyte hypertrophy during sepsis and septic shock results from prolonged exposure to endothelin precursor, M. Chopra and Avadhesh C. Sharma
Effect of nesiritide infusion duration on renal function in acutely decompensated heart failure patients, Sheryl L. Chow, Jessiva T. Peng, Mark P. Okamoto, and J. Thomas Heywood
Taking Cognitive-Behavior Therapy to School: A School-Based Mental Health Approach, Ray W. Christner, Elizabeth Forrest, Jessica Morley, and Elana Weinstein
New interpretations of the skull of a primitive bony fish Erpetoichthys calabaricus (Actinopterygii: Cladistia), Kerin M. Claeson, William E. Bemis, and James W. Hagadorn
NFATc is required for TGFß-mediated transcriptional regulation of fibronectin, Scott L. Cobbs and Jennifer L. Gooch
Reactive oxidant species and emerging therapies in clinical medicine, Farzaneh Daghigh
An Empirical Survey on Psychological Testing and the Use of the Term Psychological: Turf Battles or Clinical Necessity?, F. M. Dattilio, Katy E. Tresco, and A. Siegel
Solvent tuning of electrochemical potentials in the active sites of HiPIP versus ferredoxin, A. Dey, Francis E. Jenney Jr., M. W. Adams, E. Babini, Y. Takahashi, K. Fukuyama, K. O. Hodgson, B. Hedman, and E. I. Solomon
Sulfur K-edge X-ray absorption spectroscopy and density functional theory calculations on superoxide reductase: Role of the axial thiolate in reactivity, A. Dey, Francis E. Jenney Jr., M. W. Adams, M. K. Johnson, K. O. Hodgson, B. Hedman, and E. I. Solomon
Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation, Christiana Dimitropoulou, Lashondra West, Mary B. Field, Richard E. White, L. Manmohan Reddy, John R. Falck, and John D. Imig
Behavioral perspectives, Robert A. DiTomasso, James B. Hale, and S. M. Timchack
The behavioral model of personality disorders, Robert A. DiTomasso, James B. Hale, and Stephen M. Timchack
Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity, Shashikiran Donthamsetty, Vishakha Bhave, Mayarranjan S. Mitra, John R. Latendresse, and Harihara M. Mehendale
Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization, O. P. Edupuganti, V. Antoci Jr., S. B. King, B. Jose, Christopher S. Adams, J. Parvizi, I. M. Shapiro, A. R. Zeiger, N. J. Hickok, and E. Wickstrom
Relationships among relational communication processes and consultation outcomes for students with attention deficit hyperactivity disorder, W. P. Erchul; George J. DuPaul; P. F. Grissom; R. E. Vile Junod; A. K. Jitendra; M. C. Mannella; Katy E, Tresco; L. M. Flammer-Rivera; and R. J. Volpe
Does the Medical College Admission Test Predict Global Academic Performance in Osteopathic Medical School?, Paul Evans and Frances K. Wen
Neuropsychological functioning and recall of research consent information among drug court clients, David Festinger, K. Ratanadilok, D. Marlowe, K. Dugosh, N. Patapis, and D. Dematteo
Interpreting Intelligence Test Results for Children with Disabilities: Is Global Intelligence Relevant?, Catherine A. Fiorello, James B. Hale, James A. Holdnack, Jack A. Kavanagh, Joy Terrell, and Lisa Long
The Use of Homework in Cognitive Behavior Therapy: Working with Complex Anxiety and Insomnia, Arthur Freeman
Introduction, Arthur Freeman, Mark A. Reinecke, and Yuma I. Tomes
Management Strategies for Herpes Zoster and Postherpetic Neuralgia, Katherine E. Galluzzi
Managing Neuropathic Pain, Katherine E. Galluzzi
Providing Patient-Centered Care for Chronic Nonmalignant Pain, Katherine E. Galluzzi
What is a D.O.? How do Osteopathic Physicians Approach the Problem of Pain, Katherine E. Galluzzi
Use of AlloDerm in Primary Nipple Reconstruction to Improve Long-Term Nipple Projection, Charles E. Garramone and Benjamin Lam
Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage, Jacquelyn Gerhart, C. Neely, J. Elder, J. Pfautz, J. Perlman, L. Narciso, K. Linask, K. Knudsen, and Mindy George-Weinstein
Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: A component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon, B. Gerwe, L. Kelley, B. D. Dillard, T. Lai, Z. J. Liu, W. Tempel, L. Chen, J. Habel, Francis E. Jenney Jr., and et al.
India to introduce five-year doctor of pharmacy program., Naushad Ghilzai, Arjun P. Dutta, and David W. Newton
Loss of the alpha-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-beta, Jennifer L. Gooch, B. R. Roberts, S. L. Cobbs, and J. A. Tumlin
Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension, A. Gupta, D. T. Berg, B. Gerlitz, M. A. Richardson, E. Galbreath, S. Syed, Avadhesh C. Sharma, S. F. Lowry, and B. W. Grinnell
Neural correlates of sex differences in spatial cognition, R. C. Gur, Sarah Levin Allen, F. Irani, I. S. Panyavin, and Stephen M. Platek
Is the Demise of IQ Interpretation Justified? A Response to Special Issue Authors, James B. Hale, Catherine A. Fiorello, Jack A. Kavanagh, James A. Holdnack, and A. M. Aloe
Transforming growth factor-β1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation, F. Han, J. R. Gilbert, G. Harrison, Christopher S. Adams, T. Freeman, Z. Tao, R. Zaka, H. Liang, C. Williams, and et al.
Nongenomic, endothelium-independent effects of estrogen on human coronary smooth muscle are mediated by type I (neuronal) NOS and PI3-kinase-Akt signaling, Guichun Han, Handong Ma, Rajesh Chintala, Katsuya Miyaki, David J. R. Fulton, Scott A. Barman, and Richard E. White
Roles of religion and geography in organ donation in the African-American community., Tomia P. Harmon
TBX5 Regulates Cardiac Cell Behavior During Cardiogenesis, Cathy J. Hatcher, Minsu Kim, David Pennisi, Yan Song, Nata Diman, Marsha M. Goldstein, Takashi Mikawa, and Craig T. Basson
Once-daily tacrolimus extended-release formulation: 1-Year post-conversion in stable pediatric liver transplant recipients, Thomas Heffron, M. D. Pescovitz, S. Florman, M. Kalayoglu, S. Emre, Gregory Smallwood, K. Wisemandle, and et al.
Medical and surgical treatment of neonatal hemochromatosis: Single center experience, Thomas Heffron, Todd Pillen, David Welch, Massimo Asolati, Gregory Smallwood, Phil Hagedorn, David Solis, and et al.
Consultation-based academic intervention for children with attention deficit hyperactivity disorder: School functioning outcomes, A. K. Jitendra, George J. Dupaul, R. J. Volpe, Katy E. Tresco, R. E. V. Junod, J. G. Lutz, K. S. Cleary, Lizette M. Flammer-Rivera, and M. C. Mannella
Potassium channel blockers and openers as CNS neurologic therapeutic agents, S. I. V. Judge, P. J. Smith, Peggy E. Stewart, and C. T. Bever Jr.
Structure of the Hypothetical Protein PF0899 from Pyrococcus furiosus at 1.85 A Resolution, Laura-Lee Clancy Kelley, Bret D. Dillard, Wolfram Tempel, Lirong Chen, Neil Shaw, Doowon Lee, M. Gary Newton, Frank J. Sugar, Francis E. Jenney, Han Seung Lee, Claudia Shah, Farris L. Poole, Michael W. W. Adams, Jane S. Richardson, David C. Richardson, Zhi-Jie Liu, Bi-Cheng Wang, and John Rose
Counterfeit and substandard quality of drugs: The need for an effective and stringent regulatory control in India and other developing countries, Azhar Khan and Naushad Ghilzai
Applying Osteopathic Principles to Formulate Treatment for Patients with Chronic Pain, Michael L. Kuchera
Preventing Disruptive Behavior in the Urban Classroom: Effects of the Good Behavior Game on Student and Teacher Behavior, Amanda L. Lannie
In situ oxygen utilization in the rat intervertebral disc, D. C. Lee, Christopher S. Adams, T. J. Albert, I. M. Shapiro, S. M. Evans, and C. J. Koch
Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: Detachment strength and correlation with long-term cellular function, M. J. Lee, Christopher S. Adams, D. Boettinger, W. F. Degrado, I. M. Shapiro, R. J. Composto, and P. Ducheyne
Modeling oxygen effects in tissue-preparation neuronal-current MRI, Qingfei Luo, Ho-Ling Liu, Brent Parris, Huo Lu, David M. Senseman, and Jia-Hong Gao
Adapting judicial supervision to the risk level of drug offenders: Discharge and 6-month outcomes from a prospective matching study, D. Marlowe, David Festinger, K. Dugosh, P. Lee, and K. Benasutti
Low Back Pain, Kendra McCamey and Paul Evans
Assessment of personality disorders in childhood, George McCloskey, Peter Kane, Carrie Champ Morera, Kathryn Gipe, and Amy McClaughlin
Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs, T. Miyahara, K. Hamanaka, D. S. Weber, D. A. Drake, Mircea Anghelescu, and J. C. Parker
Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome, R. S. Muddashetty, S. Keli, C. Gross, Mei Xu, and G. J. Bassell
HERG is protected from pharmacological block by a-1,2- glucosyltransferase function, T. Nakajima, K. Hayashi, P. Viswanathan, M. Kim, Mircea Anghelescu, K. A. Barksdale, W. Shuai, J. R. Balser, and S. Kuperschmidt
The Food and Drug Administration Office of Women's Health: Impact of science on regulatory policy, D. Obias-Manno, P. E. Scott, Joseph M. Kaczmarczyk, M. Miller, E. Pinnow, L. Lee-Bishop, M. Jones-London, K. Chapman, D. Kallgren, and K. Uhl
Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation, B. Pucci, Christopher S. Adams, J. Fertala, B. C. Snyder, K. D. Mansfield, M. Tafani, T. Freeman, and I. M. Shapiro
In vitro and in vivo bactericidal effect of sol-gel/antibiotic thin films on fixation devices, S. Radin, V. Antoci Jr., N. Hickok, Christopher S. Adams, J. Parvizi, I. M. Shapiro, and P. Ducheyne
Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Barbara Boyan, and Clifton A. Baile
Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes, Srujana Rayalam, Mary Anne Della-Fera, J. Y. Yang, J. P. Hea, S. Ambati, and C. A. Baile
Resistance to combined ganciclovir and foscarnet therapy in a liver transplant recipient with possible dual-strain cytomegalovirus coinfection, John Rodriguez, Katherine Casper, Gregory Smallwood, Andrei Stieber, Carlos Fasola, Jennifer Lehneman, and Thomas Heffron
Standing on the Shoulders of Giants, Frederick Rotgers
Matrix regulation of skeletal cell apoptosis III: Mechanism of ion pair-induced apoptosis, R. Saunders, K. H. Szymczyk, I. M. Shapiro, and Christopher S. Adams
RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis, A. G. Secchi, V. Grigoriou, I. M. Shapiro, E. A. Cavalcanti-Adam, R. J. Composto, P. Ducheyne, and Christopher S. Adams
Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface, I. M. Shapiro, Christopher S. Adams, V. Srinivas, and T. A. Freeman
Sepsis-induced myocardial dysfunction, Avadhesh C. Sharma
Analysis of competitive interaction of H and R allelic forms of CD32A with rabbit IgG immune-complex, Rangaiah Shashidharamurthy, A. Amano, D. Ezekwudo, and P. Selvaraj
Region-specific neutralization of Indian cobra (Naja naja) venom by polyclonal antibody raised against the eastern regional venom: A comparative study of the venoms from three different geographical distributions, Rangaiah Shashidharamurthy and K. Kemparaju
Interleukin-4 Inhibition of Interleukin-1-Induced Expression of Matrix Metalloproteinase-3 (MMP-3) is Independent of Lipoxygenase and PPARgamma Activation in Human Gingival Fibroblasts, Denise Stewart, Masoud Javadi, Mariah Chambers, Chad Gunsolly, Grzegorz Gorski, and Ruth C. Borghaei
An Analysis of the Relationship between Irrational Beliefs and Automatic Thoughts in Predicting Distress, A. Szentagotai and Arthur Freeman
Observation of terahertz vibrations in Pyrococcus furiosus rubredoxin via impulsive coherent vibrational spectroscopy and nuclear resonance vibrational spectroscopy - interpretation by molecular mechanics, M. L. Tan, A. R. Bizzarri, Y. Xiao, S. Cannistraro, T. Ichiye, C. Manzoni, G. Cerullo, M. W. Adams, Francis E. Jenney Jr., and S. P. Cramer
Herpes Simplex Virus 1 and Chlamydophila (Chlamydia) pneumoniae promote Ab 1-42 amyloid processing in murine astrocytes linking an infectious process to Alzheimer's disease, Laura R. Triplett, Adam L. Dore, Kevin S. Kralik, Brian J. Balin, Susan T. Hingley, and Denah M. Appelt
Dispersion interactions govern the strong thermal stability of a protein, Jiří Vondrášek, T. Kubař, Francis E. Jenney Jr., Michael W. Adams, Milan Kožíšek, Jiří Černý, Vladimír Sklenář, and Pavel Hobza
Stability of caffeic acid phenethyl ester and its fluorinated derivative in rat plasma, Xinyu Wang, Phillip D. Bowman, Sean M. Kerwin, and Salomon Stavchansky
PF0610, a novel winged helix-turn-helix variant possessing a rubredoxin-like Zn ribbon motif from the hyperthermophilic archaeon, Pyrococcus furiosus, X. Wang, H. Lee, F. J. Sugar, Francis E. Jenney Jr., Michael W. Adams, and J. H. Prestegard
Working with adult survivors of sexual and physical abuse, Beverly White
Hormone replacement therapy and cardiovascular function: Evidence for dual and opposite effects of estrogen on vascular reactivity, Richard E. White
Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes, Jeongyeh Yang, Mary Anne Della-Fera, Srujana Rayalam, Suresh Ambati, and Clifton A. Baile
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis, Jeongyeh Yang, Mary Anne Della-Fera, Srujana Rayalam, and Clifton A. Baile
A Critical Role for the Co-Repressor N-CoR in Erythroid Differentiation and Heme Synthesis, Dianzheng Zhang, Ellen Cho, and Jiemin Wong
An enhancer mutant of Arabidopsis salt overly sensitive 3 mediates both ion homeostasis and the oxidative stress response, J. Zhu, X. Fu, Y. Koo, J. Zhu, Francis E. Jenney Jr, Michael W. Adams, Y. Zhu, H. Shi, S. Yub, and et al.
Submissions from 2006
Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization, Yun Bai and Wei-Chiang Shen
Cyclic nucleotide and protein kinase signaling in hypertensive pulmonary arterial smooth muscle, Scott A. Barman, Shu Zhu, and Richard E. White
Protein kinase signaling in hypertensive pulmonary arterial smooth muscle, Scott A. Barman, Shu Zhu, and Richard E. White
The National Report Card on the State of Emergency Medicine, John W. Becher
Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned guinea pig trabeculae, Marcus G. Bell, E. B. Lankford, G. E. Gonye, G. C. R. Ellis-Davies, D. A. Martyn, M. Regnier, and Robert J. Barsotti
Kinetics of Cardiac Thin-Filament Activation Probed by Fluorescence Polarization of Rhodamine-Labeled Troponin C in Skinned Guinea Pig Trabeculae, Marcus G. Bell, Edward B. Lankford, Gregory E. Gonye, Graham C. R. Ellis-Davies, Donald A. Martyn, Michael Regnier, and Robert J. Barsotti
Effect of night vision goggles on performance of advanced life support skills by emergency personnel., Savoy Brummer, Edward T Dickinson, Frances S Shofer, James P. McCans, and C Crawford Mechem
PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG, Jason O. Burnette and Richard E. White
Influence of Route of Entry to a Physician Assistant Education Program on Selected Characteristics of Practices of Physician Assistants, John M. Cavenagh
Presynaptic a1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons, Qian Chen, D. P. Li, and H. L. Pan
Regulation of synaptic input to hypothalamic presympathetic neurons by GABAB receptors, Qian Chen and H. L. Pan