Title

Neuronal CaMKII acts as a structural kinase

Document Type

Article

Publication Date

2009

Abstract

CaMKII, calcium/calmodulin dependent protein kinase, is an active kinase in the cell that phosphorylates a number of substrates including several cytoskeletal and signaling proteins. In addition to kinase activity, the ß isoform of CaMKII also contains an F-actin binding region. We recently identified a new F-actin rich structure in developing cortical neurons that endogenous CaMKIIß bound. In nonneuronal cells and dendrite spines of hippocampal neurons where an interaction between CaMKIIß and F-actin has been identified, CaMKIIß was involved in regulating the differentiation of dendrite spines and formation of synapses. In this study, we took advantage of the temporal and spatial regulation of CaMKII isoforms to reveal a specific role for CaMKIIß in binding and stability of a novel F-actin rich structure. We used FRAP and colocalization assays in this CaMKJIß rich system to demonstrate a structural, rather than enzymatic, role of CaMKIIß. In this addendum, we further discuss the significance of this study and the possible implication to the field. ©2009 Landes Bioscience.

Publication Title

Communicative and Integrative Biology

Volume

2

Issue

1

First Page

40

Last Page

41

Comments

This article was published in Communicative and Integrative Biology, Volume 2, Issue 1, Pages 40-41.

The published version is available at http://dx.doi.org/10.4161/cib.2.1.7426 .

Copyright © 2009 Taylor and Francis.

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